HIV infection presenting as bone marrow cryptococcosis

Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspirat...

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Autores principales: Dharwadkar, Arpana, Vimal, Shruti, Buch, Archana C., Panicker, N. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139979/
https://www.ncbi.nlm.nih.gov/pubmed/25161991
http://dx.doi.org/10.4103/2277-9175.135161
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author Dharwadkar, Arpana
Vimal, Shruti
Buch, Archana C.
Panicker, N. K.
author_facet Dharwadkar, Arpana
Vimal, Shruti
Buch, Archana C.
Panicker, N. K.
author_sort Dharwadkar, Arpana
collection PubMed
description Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspiration showed granulomas along with cryptococcal yeast forms. The ELISA test for detection of human immunodeficiency virus (HIV) antigen was positive. Disseminated cryptococcosis can develop as the first manifestation of HIV infection in previously healthy individuals and granulomas in such bone marrow aspiration smears are a valuable clue to an underlying opportunistic infection.
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spelling pubmed-41399792014-08-26 HIV infection presenting as bone marrow cryptococcosis Dharwadkar, Arpana Vimal, Shruti Buch, Archana C. Panicker, N. K. Adv Biomed Res Case Report Disseminated cryptococcal infection is an uncommon initial manifestation in immunocompromised patients. We report a rare case of a 40-year-old female presenting with fever and burning epigastrium. Peripheral blood film revealed a leukoerythroblastic picture with thrombocytopenia. Bone marrow aspiration showed granulomas along with cryptococcal yeast forms. The ELISA test for detection of human immunodeficiency virus (HIV) antigen was positive. Disseminated cryptococcosis can develop as the first manifestation of HIV infection in previously healthy individuals and granulomas in such bone marrow aspiration smears are a valuable clue to an underlying opportunistic infection. Medknow Publications & Media Pvt Ltd 2014-06-25 /pmc/articles/PMC4139979/ /pubmed/25161991 http://dx.doi.org/10.4103/2277-9175.135161 Text en Copyright: © 2014 Dharwadkar. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Case Report
Dharwadkar, Arpana
Vimal, Shruti
Buch, Archana C.
Panicker, N. K.
HIV infection presenting as bone marrow cryptococcosis
title HIV infection presenting as bone marrow cryptococcosis
title_full HIV infection presenting as bone marrow cryptococcosis
title_fullStr HIV infection presenting as bone marrow cryptococcosis
title_full_unstemmed HIV infection presenting as bone marrow cryptococcosis
title_short HIV infection presenting as bone marrow cryptococcosis
title_sort hiv infection presenting as bone marrow cryptococcosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139979/
https://www.ncbi.nlm.nih.gov/pubmed/25161991
http://dx.doi.org/10.4103/2277-9175.135161
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