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Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in t...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140125/ https://www.ncbi.nlm.nih.gov/pubmed/25165471 http://dx.doi.org/10.1155/2014/529314 |
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author | Zhu, Rong Yang, Jing Xu, Ling Dai, Weiqi Wang, Fan Shen, Miao Zhang, Yan Zhang, Huawei Chen, Kan Cheng, Ping Wang, Chengfen Zheng, Yuanyuan Li, Jingjing Lu, Jie Zhou, Yingqun Wu, Dong Guo, Chuanyong |
author_facet | Zhu, Rong Yang, Jing Xu, Ling Dai, Weiqi Wang, Fan Shen, Miao Zhang, Yan Zhang, Huawei Chen, Kan Cheng, Ping Wang, Chengfen Zheng, Yuanyuan Li, Jingjing Lu, Jie Zhou, Yingqun Wu, Dong Guo, Chuanyong |
author_sort | Zhu, Rong |
collection | PubMed |
description | Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in the diagnosis of HCC. Following a systematic review of relevant studies, Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Data are presented as forest plots and summary receiver operating characteristic curve (SROC) analysis was used to summarize the overall test performance. Results. Twelve studies were included in our meta-analysis. The overall sensitivity, specificity, PLR, and NLR of DCP for the detection of HCC in the studies included were 71% (95%CI: 68%–73%), 84% (95%CI: 83%–86%), 6.48 (95%CI: 4.22–9.93), and 0.33 (95%CI: 0.25–0.43), respectively. The area under the SROC curve was 0.8930 and the Q index was 0.8238. Significant heterogeneity was found. Conclusion. This meta-analysis indicated that DCP had moderate diagnostic accuracy in HCC. Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future. |
format | Online Article Text |
id | pubmed-4140125 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41401252014-08-27 Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis Zhu, Rong Yang, Jing Xu, Ling Dai, Weiqi Wang, Fan Shen, Miao Zhang, Yan Zhang, Huawei Chen, Kan Cheng, Ping Wang, Chengfen Zheng, Yuanyuan Li, Jingjing Lu, Jie Zhou, Yingqun Wu, Dong Guo, Chuanyong Gastroenterol Res Pract Review Article Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in the diagnosis of HCC. Following a systematic review of relevant studies, Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Data are presented as forest plots and summary receiver operating characteristic curve (SROC) analysis was used to summarize the overall test performance. Results. Twelve studies were included in our meta-analysis. The overall sensitivity, specificity, PLR, and NLR of DCP for the detection of HCC in the studies included were 71% (95%CI: 68%–73%), 84% (95%CI: 83%–86%), 6.48 (95%CI: 4.22–9.93), and 0.33 (95%CI: 0.25–0.43), respectively. The area under the SROC curve was 0.8930 and the Q index was 0.8238. Significant heterogeneity was found. Conclusion. This meta-analysis indicated that DCP had moderate diagnostic accuracy in HCC. Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future. Hindawi Publishing Corporation 2014 2014-08-06 /pmc/articles/PMC4140125/ /pubmed/25165471 http://dx.doi.org/10.1155/2014/529314 Text en Copyright © 2014 Rong Zhu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Rong Yang, Jing Xu, Ling Dai, Weiqi Wang, Fan Shen, Miao Zhang, Yan Zhang, Huawei Chen, Kan Cheng, Ping Wang, Chengfen Zheng, Yuanyuan Li, Jingjing Lu, Jie Zhou, Yingqun Wu, Dong Guo, Chuanyong Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title | Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title_full | Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title_fullStr | Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title_full_unstemmed | Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title_short | Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis |
title_sort | diagnostic performance of des-γ-carboxy prothrombin for hepatocellular carcinoma: a meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140125/ https://www.ncbi.nlm.nih.gov/pubmed/25165471 http://dx.doi.org/10.1155/2014/529314 |
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