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Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis

Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in t...

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Autores principales: Zhu, Rong, Yang, Jing, Xu, Ling, Dai, Weiqi, Wang, Fan, Shen, Miao, Zhang, Yan, Zhang, Huawei, Chen, Kan, Cheng, Ping, Wang, Chengfen, Zheng, Yuanyuan, Li, Jingjing, Lu, Jie, Zhou, Yingqun, Wu, Dong, Guo, Chuanyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140125/
https://www.ncbi.nlm.nih.gov/pubmed/25165471
http://dx.doi.org/10.1155/2014/529314
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author Zhu, Rong
Yang, Jing
Xu, Ling
Dai, Weiqi
Wang, Fan
Shen, Miao
Zhang, Yan
Zhang, Huawei
Chen, Kan
Cheng, Ping
Wang, Chengfen
Zheng, Yuanyuan
Li, Jingjing
Lu, Jie
Zhou, Yingqun
Wu, Dong
Guo, Chuanyong
author_facet Zhu, Rong
Yang, Jing
Xu, Ling
Dai, Weiqi
Wang, Fan
Shen, Miao
Zhang, Yan
Zhang, Huawei
Chen, Kan
Cheng, Ping
Wang, Chengfen
Zheng, Yuanyuan
Li, Jingjing
Lu, Jie
Zhou, Yingqun
Wu, Dong
Guo, Chuanyong
author_sort Zhu, Rong
collection PubMed
description Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in the diagnosis of HCC. Following a systematic review of relevant studies, Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Data are presented as forest plots and summary receiver operating characteristic curve (SROC) analysis was used to summarize the overall test performance. Results. Twelve studies were included in our meta-analysis. The overall sensitivity, specificity, PLR, and NLR of DCP for the detection of HCC in the studies included were 71% (95%CI: 68%–73%), 84% (95%CI: 83%–86%), 6.48 (95%CI: 4.22–9.93), and 0.33 (95%CI: 0.25–0.43), respectively. The area under the SROC curve was 0.8930 and the Q index was 0.8238. Significant heterogeneity was found. Conclusion. This meta-analysis indicated that DCP had moderate diagnostic accuracy in HCC. Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future.
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spelling pubmed-41401252014-08-27 Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis Zhu, Rong Yang, Jing Xu, Ling Dai, Weiqi Wang, Fan Shen, Miao Zhang, Yan Zhang, Huawei Chen, Kan Cheng, Ping Wang, Chengfen Zheng, Yuanyuan Li, Jingjing Lu, Jie Zhou, Yingqun Wu, Dong Guo, Chuanyong Gastroenterol Res Pract Review Article Background. There have been many reports on des-γ-carboxy prothrombin (DCP) as a promising serum marker in the diagnosis of hepatocellular carcinoma (HCC); however, the results are inconsistent and even conflicting. Methods. This meta-analysis was performed to investigate the performance of DCP in the diagnosis of HCC. Following a systematic review of relevant studies, Meta-DiSc 1.4 software was used to extract data and to calculate the overall sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Data are presented as forest plots and summary receiver operating characteristic curve (SROC) analysis was used to summarize the overall test performance. Results. Twelve studies were included in our meta-analysis. The overall sensitivity, specificity, PLR, and NLR of DCP for the detection of HCC in the studies included were 71% (95%CI: 68%–73%), 84% (95%CI: 83%–86%), 6.48 (95%CI: 4.22–9.93), and 0.33 (95%CI: 0.25–0.43), respectively. The area under the SROC curve was 0.8930 and the Q index was 0.8238. Significant heterogeneity was found. Conclusion. This meta-analysis indicated that DCP had moderate diagnostic accuracy in HCC. Further studies with rigorous design, large sample size, and mmultiregional cooperation are needed in the future. Hindawi Publishing Corporation 2014 2014-08-06 /pmc/articles/PMC4140125/ /pubmed/25165471 http://dx.doi.org/10.1155/2014/529314 Text en Copyright © 2014 Rong Zhu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhu, Rong
Yang, Jing
Xu, Ling
Dai, Weiqi
Wang, Fan
Shen, Miao
Zhang, Yan
Zhang, Huawei
Chen, Kan
Cheng, Ping
Wang, Chengfen
Zheng, Yuanyuan
Li, Jingjing
Lu, Jie
Zhou, Yingqun
Wu, Dong
Guo, Chuanyong
Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title_full Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title_fullStr Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title_full_unstemmed Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title_short Diagnostic Performance of Des-γ-carboxy Prothrombin for Hepatocellular Carcinoma: A Meta-Analysis
title_sort diagnostic performance of des-γ-carboxy prothrombin for hepatocellular carcinoma: a meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140125/
https://www.ncbi.nlm.nih.gov/pubmed/25165471
http://dx.doi.org/10.1155/2014/529314
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