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Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops

Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium...

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Detalles Bibliográficos
Autores principales: Ambrosone, Luigi, Guerra, Germano, Cinelli, Mariapia, Filippelli, Mariaelena, Mosca, Monica, Vizzarri, Francesco, Giorgio, Dario, Costagliola, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140135/
https://www.ncbi.nlm.nih.gov/pubmed/25165705
http://dx.doi.org/10.1155/2014/471642
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author Ambrosone, Luigi
Guerra, Germano
Cinelli, Mariapia
Filippelli, Mariaelena
Mosca, Monica
Vizzarri, Francesco
Giorgio, Dario
Costagliola, Ciro
author_facet Ambrosone, Luigi
Guerra, Germano
Cinelli, Mariapia
Filippelli, Mariaelena
Mosca, Monica
Vizzarri, Francesco
Giorgio, Dario
Costagliola, Ciro
author_sort Ambrosone, Luigi
collection PubMed
description Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays.
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spelling pubmed-41401352014-08-27 Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops Ambrosone, Luigi Guerra, Germano Cinelli, Mariapia Filippelli, Mariaelena Mosca, Monica Vizzarri, Francesco Giorgio, Dario Costagliola, Ciro Biomed Res Int Research Article Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays. Hindawi Publishing Corporation 2014 2014-08-06 /pmc/articles/PMC4140135/ /pubmed/25165705 http://dx.doi.org/10.1155/2014/471642 Text en Copyright © 2014 Luigi Ambrosone et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ambrosone, Luigi
Guerra, Germano
Cinelli, Mariapia
Filippelli, Mariaelena
Mosca, Monica
Vizzarri, Francesco
Giorgio, Dario
Costagliola, Ciro
Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title_full Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title_fullStr Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title_full_unstemmed Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title_short Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
title_sort corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140135/
https://www.ncbi.nlm.nih.gov/pubmed/25165705
http://dx.doi.org/10.1155/2014/471642
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