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Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops
Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140135/ https://www.ncbi.nlm.nih.gov/pubmed/25165705 http://dx.doi.org/10.1155/2014/471642 |
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author | Ambrosone, Luigi Guerra, Germano Cinelli, Mariapia Filippelli, Mariaelena Mosca, Monica Vizzarri, Francesco Giorgio, Dario Costagliola, Ciro |
author_facet | Ambrosone, Luigi Guerra, Germano Cinelli, Mariapia Filippelli, Mariaelena Mosca, Monica Vizzarri, Francesco Giorgio, Dario Costagliola, Ciro |
author_sort | Ambrosone, Luigi |
collection | PubMed |
description | Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays. |
format | Online Article Text |
id | pubmed-4140135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41401352014-08-27 Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops Ambrosone, Luigi Guerra, Germano Cinelli, Mariapia Filippelli, Mariaelena Mosca, Monica Vizzarri, Francesco Giorgio, Dario Costagliola, Ciro Biomed Res Int Research Article Different liposomal formulations were prepared to identify those capable of forming eyedrops for corneal diseases. Liposomes with neutral or slightly positive surface charge interact very well with the cornea. Then these formulations were loaded with verbascoside to heal a burn of corneal epithelium induced by alkali. The cornea surface affected involved in wound was monitored as a function of time. Experimental results were modeled by balance equation between the rate of healing, due to the flow of phenylpropanoid, and growth of the wound. The results indicate a latency time of only three hours and furthermore the corneal epithelium heals in 48 hours. Thus, the topical administration of verbascoside appears to reduce the action time of cells, as verified by histochemical and immunofluorescence assays. Hindawi Publishing Corporation 2014 2014-08-06 /pmc/articles/PMC4140135/ /pubmed/25165705 http://dx.doi.org/10.1155/2014/471642 Text en Copyright © 2014 Luigi Ambrosone et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ambrosone, Luigi Guerra, Germano Cinelli, Mariapia Filippelli, Mariaelena Mosca, Monica Vizzarri, Francesco Giorgio, Dario Costagliola, Ciro Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title | Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title_full | Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title_fullStr | Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title_full_unstemmed | Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title_short | Corneal Epithelial Wound Healing Promoted by Verbascoside-Based Liposomal Eyedrops |
title_sort | corneal epithelial wound healing promoted by verbascoside-based liposomal eyedrops |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140135/ https://www.ncbi.nlm.nih.gov/pubmed/25165705 http://dx.doi.org/10.1155/2014/471642 |
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