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Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase

The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II)-dependent oxygenases. KDM6A (UTX) and KDM6B (JMJD3) are KDM6 subfamily members that catalyze demethylation of N(ϵ)-methylated histone 3 lysine 27 (H3K27), a mark important for transcriptional repression. Despite reports stating...

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Detalles Bibliográficos
Autores principales:	Walport, Louise J., Hopkinson, Richard J., Vollmar, Melanie, Madden, Sarah K., Gileadi, Carina, Oppermann, Udo, Schofield, Christopher J., Johansson, Catrine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140284/ https://www.ncbi.nlm.nih.gov/pubmed/24798337 http://dx.doi.org/10.1074/jbc.M114.555052

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