Poly(oligonucleotide)

[Image: see text] Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-open...

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Detalles Bibliográficos
Autores principales: James, Carrie R., Rush, Anthony M., Insley, Thomas, Vuković, Lela, Adamiak, Lisa, Král, Petr, Gianneschi, Nathan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140503/
https://www.ncbi.nlm.nih.gov/pubmed/25077676
http://dx.doi.org/10.1021/ja503142s
Descripción
Sumario:[Image: see text] Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH(2))(C(5)H(5)N)(2)(Cl)(2)RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.

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