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Improving the Serum Stability of Site-Specific Antibody Conjugates with Sulfone Linkers

[Image: see text] Current routes for synthesizing antibody–drug conjugates commonly rely on maleimide linkers to react with cysteine thiols. However, thioether exchange with metabolites and serum proteins can compromise conjugate stability and diminish in vivo efficacy. We report the application of...

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Detalles Bibliográficos
Autores principales:	Patterson, James T., Asano, Shigehiro, Li, Xiuling, Rader, Christoph, Barbas, Carlos F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140540/ https://www.ncbi.nlm.nih.gov/pubmed/25099687 http://dx.doi.org/10.1021/bc500276m

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