Cargando…
Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock
Small ruminant lentivirus (SRLV), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of US sheep. Like human immunodeficiency virus, SRLV is a macrophage-tropic lentivirus that causes lifelong infection. The production impacts from SRLV are due to a range of disease symp...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140605/ https://www.ncbi.nlm.nih.gov/pubmed/24934128 http://dx.doi.org/10.1111/age.12181 |
_version_ | 1782331531257184256 |
---|---|
author | Alshanbari, F A Mousel, M R Reynolds, J O Herrmann-Hoesing, L M Highland, M A Lewis, G S White, S N |
author_facet | Alshanbari, F A Mousel, M R Reynolds, J O Herrmann-Hoesing, L M Highland, M A Lewis, G S White, S N |
author_sort | Alshanbari, F A |
collection | PubMed |
description | Small ruminant lentivirus (SRLV), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of US sheep. Like human immunodeficiency virus, SRLV is a macrophage-tropic lentivirus that causes lifelong infection. The production impacts from SRLV are due to a range of disease symptoms, including pneumonia, arthritis, mastitis, body condition wasting and encephalitis. There is no cure and no effective vaccine for preventing SRLV infection. However, breed differences in prevalence and proviral concentration indicate a genetic basis for susceptibility to SRLV. Animals with high blood proviral concentration show increased tissue lesion severity, so proviral concentration represents a live animal test for control post-infection in terms of proviral replication and disease severity. Recently, it was found that sheep with two copies of TMEM154 haplotype 1 (encoding lysine at position 35) had lower odds of SRLV infection. In this study, we examined the relationship between SRLV control post-infection and variants in two genes, TMEM154 and CCR5, in four flocks containing 1403 SRLV-positive sheep. We found two copies of TMEM154 haplotype 1 were associated with lower SRLV proviral concentration in one flock (P < 0.02). This identified the same favorable diplotype for SRLV control post-infection as for odds of infection. However, frequencies of haplotypes 2 and 3 were too low in the other three flocks to test. The CCR5 promoter deletion did not have consistent association with SRLV proviral concentration. Future work in flocks with more balanced allele frequencies is needed to confirm or refute TMEM154 association with control of SRLV post-infection. |
format | Online Article Text |
id | pubmed-4140605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41406052014-09-22 Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock Alshanbari, F A Mousel, M R Reynolds, J O Herrmann-Hoesing, L M Highland, M A Lewis, G S White, S N Anim Genet Articles Small ruminant lentivirus (SRLV), also called ovine progressive pneumonia virus or maedi-visna, is present in 24% of US sheep. Like human immunodeficiency virus, SRLV is a macrophage-tropic lentivirus that causes lifelong infection. The production impacts from SRLV are due to a range of disease symptoms, including pneumonia, arthritis, mastitis, body condition wasting and encephalitis. There is no cure and no effective vaccine for preventing SRLV infection. However, breed differences in prevalence and proviral concentration indicate a genetic basis for susceptibility to SRLV. Animals with high blood proviral concentration show increased tissue lesion severity, so proviral concentration represents a live animal test for control post-infection in terms of proviral replication and disease severity. Recently, it was found that sheep with two copies of TMEM154 haplotype 1 (encoding lysine at position 35) had lower odds of SRLV infection. In this study, we examined the relationship between SRLV control post-infection and variants in two genes, TMEM154 and CCR5, in four flocks containing 1403 SRLV-positive sheep. We found two copies of TMEM154 haplotype 1 were associated with lower SRLV proviral concentration in one flock (P < 0.02). This identified the same favorable diplotype for SRLV control post-infection as for odds of infection. However, frequencies of haplotypes 2 and 3 were too low in the other three flocks to test. The CCR5 promoter deletion did not have consistent association with SRLV proviral concentration. Future work in flocks with more balanced allele frequencies is needed to confirm or refute TMEM154 association with control of SRLV post-infection. Blackwell Publishing Ltd 2014-08 2014-06-17 /pmc/articles/PMC4140605/ /pubmed/24934128 http://dx.doi.org/10.1111/age.12181 Text en Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Animal Genetics published by John Wiley & Sons Ltd on behalf of Stichting International Foundation for Animal Genetics. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Alshanbari, F A Mousel, M R Reynolds, J O Herrmann-Hoesing, L M Highland, M A Lewis, G S White, S N Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title | Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title_full | Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title_fullStr | Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title_full_unstemmed | Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title_short | Mutations in Ovis aries TMEM154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
title_sort | mutations in ovis aries tmem154 are associated with lower small ruminant lentivirus proviral concentration in one sheep flock |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140605/ https://www.ncbi.nlm.nih.gov/pubmed/24934128 http://dx.doi.org/10.1111/age.12181 |
work_keys_str_mv | AT alshanbarifa mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT mouselmr mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT reynoldsjo mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT herrmannhoesinglm mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT highlandma mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT lewisgs mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock AT whitesn mutationsinovisariestmem154areassociatedwithlowersmallruminantlentivirusproviralconcentrationinonesheepflock |