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Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife

INTRODUCTION: Persistence of cervical infection caused by human papillomavirus (HPV) types with high oncogenic risk may lead to cervical intraepithelial neoplasia (CIN). The aim of the present study was to evaluate whether, in HIV-positive women, the presence of aneuploidy in cervical cell samples i...

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Autores principales: Martins, Albert Eduardo Silva, Lucena-Silva, Norma, Garcia, Renan Gomes, Welkovic, Stefan, Barbosa, Aureliana, Menezes, Maria Luiza Bezerra, Tenório, Terezinha, Maruza, Magda, Ximenes, Ricardo A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140713/
https://www.ncbi.nlm.nih.gov/pubmed/25144309
http://dx.doi.org/10.1371/journal.pone.0104801
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author Martins, Albert Eduardo Silva
Lucena-Silva, Norma
Garcia, Renan Gomes
Welkovic, Stefan
Barbosa, Aureliana
Menezes, Maria Luiza Bezerra
Tenório, Terezinha
Maruza, Magda
Ximenes, Ricardo A. A.
author_facet Martins, Albert Eduardo Silva
Lucena-Silva, Norma
Garcia, Renan Gomes
Welkovic, Stefan
Barbosa, Aureliana
Menezes, Maria Luiza Bezerra
Tenório, Terezinha
Maruza, Magda
Ximenes, Ricardo A. A.
author_sort Martins, Albert Eduardo Silva
collection PubMed
description INTRODUCTION: Persistence of cervical infection caused by human papillomavirus (HPV) types with high oncogenic risk may lead to cervical intraepithelial neoplasia (CIN). The aim of the present study was to evaluate whether, in HIV-positive women, the presence of aneuploidy in cervical cell samples is associated with presence and evolution of CIN. METHODS: The present study had two stages. In the first stage, comprising a cross-sectional study, the association between the presence of aneuploidy seen via flow cytometry and sociodemographic characteristics, habits and characteristics relating to HPV and HIV infection was analyzed. In the second stage, comprising a cohort study, it was investigated whether aneuploidy was predictive of CIN evolution. RESULTS: No association was observed between the presence of aneuploidy and HPV infection, or between its presence and alterations seen in oncotic cytological analysis. On the other hand, aneuploidy was associated with the presence of CIN (p = 0.030) in histological analysis and with nonuse of antiretroviral therapy (p = 0.001). Most of the HIV-positive women (234/272) presented normal CD4+ T lymphocyte counts (greater than 350 cells/mm(3)) and showed a greater aneuploidy regression rate (77.5%) than a progression rate (23.9%) over a follow-up of up to two years. CONCLUSION: Although there was an association between the presence of cervical tissue lesions and the DNA index, the latter was not predictive of progression of the cervical lesion. This suggests that progression of the cervical lesion to cancer in HIV-positive women may also be changed through improvement of the immunological state enabled by using antiretroviral therapy.
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spelling pubmed-41407132014-08-25 Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife Martins, Albert Eduardo Silva Lucena-Silva, Norma Garcia, Renan Gomes Welkovic, Stefan Barbosa, Aureliana Menezes, Maria Luiza Bezerra Tenório, Terezinha Maruza, Magda Ximenes, Ricardo A. A. PLoS One Research Article INTRODUCTION: Persistence of cervical infection caused by human papillomavirus (HPV) types with high oncogenic risk may lead to cervical intraepithelial neoplasia (CIN). The aim of the present study was to evaluate whether, in HIV-positive women, the presence of aneuploidy in cervical cell samples is associated with presence and evolution of CIN. METHODS: The present study had two stages. In the first stage, comprising a cross-sectional study, the association between the presence of aneuploidy seen via flow cytometry and sociodemographic characteristics, habits and characteristics relating to HPV and HIV infection was analyzed. In the second stage, comprising a cohort study, it was investigated whether aneuploidy was predictive of CIN evolution. RESULTS: No association was observed between the presence of aneuploidy and HPV infection, or between its presence and alterations seen in oncotic cytological analysis. On the other hand, aneuploidy was associated with the presence of CIN (p = 0.030) in histological analysis and with nonuse of antiretroviral therapy (p = 0.001). Most of the HIV-positive women (234/272) presented normal CD4+ T lymphocyte counts (greater than 350 cells/mm(3)) and showed a greater aneuploidy regression rate (77.5%) than a progression rate (23.9%) over a follow-up of up to two years. CONCLUSION: Although there was an association between the presence of cervical tissue lesions and the DNA index, the latter was not predictive of progression of the cervical lesion. This suggests that progression of the cervical lesion to cancer in HIV-positive women may also be changed through improvement of the immunological state enabled by using antiretroviral therapy. Public Library of Science 2014-08-21 /pmc/articles/PMC4140713/ /pubmed/25144309 http://dx.doi.org/10.1371/journal.pone.0104801 Text en © 2014 Martins et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Martins, Albert Eduardo Silva
Lucena-Silva, Norma
Garcia, Renan Gomes
Welkovic, Stefan
Barbosa, Aureliana
Menezes, Maria Luiza Bezerra
Tenório, Terezinha
Maruza, Magda
Ximenes, Ricardo A. A.
Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title_full Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title_fullStr Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title_full_unstemmed Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title_short Prognostic Evaluation of DNA Index in HIV-HPV Co-Infected Women Cervical Samples Attending in Reference Centers for HIV-AIDS in Recife
title_sort prognostic evaluation of dna index in hiv-hpv co-infected women cervical samples attending in reference centers for hiv-aids in recife
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140713/
https://www.ncbi.nlm.nih.gov/pubmed/25144309
http://dx.doi.org/10.1371/journal.pone.0104801
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