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Bacterial proteins and peptides in cancer therapy: Today and tomorrow
Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts have been made focused on understanding how cancer grows and responds to drugs. The dominant drug-development paradigm has been the “one drug, one target.” Based on that, the two main targeted therapies devel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140868/ https://www.ncbi.nlm.nih.gov/pubmed/24875003 http://dx.doi.org/10.4161/bioe.29266 |
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author | Chakrabarty, Ananda M Bernardes, Nuno Fialho, Arsenio M |
author_facet | Chakrabarty, Ananda M Bernardes, Nuno Fialho, Arsenio M |
author_sort | Chakrabarty, Ananda M |
collection | PubMed |
description | Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts have been made focused on understanding how cancer grows and responds to drugs. The dominant drug-development paradigm has been the “one drug, one target.” Based on that, the two main targeted therapies developed to combat cancer include the use of tyrosine kinase inhibitors and monoclonal antibodies. Development of drug resistance and side effects represent the major limiting factors for their use in cancer treatment. Nowadays, a new paradigm for cancer drug discovery is emerging wherein multi-targeted approaches gain ground in cancer therapy. Therefore, to overcome resistance to therapy, it is clear that a new generation of drugs is urgently needed. Here, regarding the concept of multi-targeted therapy, we discuss the challenges of using bacterial proteins and peptides as a new generation of effective anti-cancer drugs. |
format | Online Article Text |
id | pubmed-4140868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-41408682015-07-01 Bacterial proteins and peptides in cancer therapy: Today and tomorrow Chakrabarty, Ananda M Bernardes, Nuno Fialho, Arsenio M Bioengineered Review Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts have been made focused on understanding how cancer grows and responds to drugs. The dominant drug-development paradigm has been the “one drug, one target.” Based on that, the two main targeted therapies developed to combat cancer include the use of tyrosine kinase inhibitors and monoclonal antibodies. Development of drug resistance and side effects represent the major limiting factors for their use in cancer treatment. Nowadays, a new paradigm for cancer drug discovery is emerging wherein multi-targeted approaches gain ground in cancer therapy. Therefore, to overcome resistance to therapy, it is clear that a new generation of drugs is urgently needed. Here, regarding the concept of multi-targeted therapy, we discuss the challenges of using bacterial proteins and peptides as a new generation of effective anti-cancer drugs. Landes Bioscience 2014-07-01 2014-05-29 /pmc/articles/PMC4140868/ /pubmed/24875003 http://dx.doi.org/10.4161/bioe.29266 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Chakrabarty, Ananda M Bernardes, Nuno Fialho, Arsenio M Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title | Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title_full | Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title_fullStr | Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title_full_unstemmed | Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title_short | Bacterial proteins and peptides in cancer therapy: Today and tomorrow |
title_sort | bacterial proteins and peptides in cancer therapy: today and tomorrow |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140868/ https://www.ncbi.nlm.nih.gov/pubmed/24875003 http://dx.doi.org/10.4161/bioe.29266 |
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