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mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study
Unfolded or misfolded proteins in the endoplasmic reticulum (ER) trigger an adaptive ER stress response known as unfolded protein response (UPR). Depending on the severity of ER stress, either autophagy-controlled survival or apoptotic cell death can be induced. The molecular mechanisms by which UPR...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141208/ https://www.ncbi.nlm.nih.gov/pubmed/25161878 http://dx.doi.org/10.1016/j.fob.2014.07.006 |