Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

DNA replication errors that persist as mismatch mutations make up the molecular fingerprint of mismatch repair (MMR)-deficient tumors and convey them with resistance to standard therapy. Using whole-genome and whole-exome sequencing, we here confirm an MMR-deficient mutation signature that is distin...

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Detalles Bibliográficos
Autores principales: Zhao, Hui, Thienpont, Bernard, Yesilyurt, Betül Tuba, Moisse, Matthieu, Reumers, Joke, Coenegrachts, Lieve, Sagaert, Xavier, Schrauwen, Stefanie, Smeets, Dominiek, Matthijs, Gert, Aerts, Stein, Cools, Jan, Metcalf, Alex, Spurdle, Amanda, Amant, Frederic, Lambrechts, Diether
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141275/
https://www.ncbi.nlm.nih.gov/pubmed/25085081
http://dx.doi.org/10.7554/eLife.02725

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