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Addition of CF(3) across unsaturated moieties: a powerful functionalization tool

In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scena...

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Detalles Bibliográficos
Autores principales: Merino, Estíbaliz, Nevado, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141301/
https://www.ncbi.nlm.nih.gov/pubmed/24789472
http://dx.doi.org/10.1039/c4cs00025k
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author Merino, Estíbaliz
Nevado, Cristina
author_facet Merino, Estíbaliz
Nevado, Cristina
author_sort Merino, Estíbaliz
collection PubMed
description In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF(3) and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential.
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spelling pubmed-41413012014-09-04 Addition of CF(3) across unsaturated moieties: a powerful functionalization tool Merino, Estíbaliz Nevado, Cristina Chem Soc Rev Chemistry In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF(3) and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential. Royal Society of Chemistry 2014-09-21 2014-05-02 /pmc/articles/PMC4141301/ /pubmed/24789472 http://dx.doi.org/10.1039/c4cs00025k Text en This journal is © The Royal Society of Chemistry 2014 https://creativecommons.org/licenses/by-nc/2.0/uk/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/ (https://creativecommons.org/licenses/by-nc/2.0/uk/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Merino, Estíbaliz
Nevado, Cristina
Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title_full Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title_fullStr Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title_full_unstemmed Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title_short Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
title_sort addition of cf(3) across unsaturated moieties: a powerful functionalization tool
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141301/
https://www.ncbi.nlm.nih.gov/pubmed/24789472
http://dx.doi.org/10.1039/c4cs00025k
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