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Addition of CF(3) across unsaturated moieties: a powerful functionalization tool
In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scena...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141301/ https://www.ncbi.nlm.nih.gov/pubmed/24789472 http://dx.doi.org/10.1039/c4cs00025k |
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author | Merino, Estíbaliz Nevado, Cristina |
author_facet | Merino, Estíbaliz Nevado, Cristina |
author_sort | Merino, Estíbaliz |
collection | PubMed |
description | In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF(3) and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential. |
format | Online Article Text |
id | pubmed-4141301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-41413012014-09-04 Addition of CF(3) across unsaturated moieties: a powerful functionalization tool Merino, Estíbaliz Nevado, Cristina Chem Soc Rev Chemistry In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF(3) groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF(3) and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential. Royal Society of Chemistry 2014-09-21 2014-05-02 /pmc/articles/PMC4141301/ /pubmed/24789472 http://dx.doi.org/10.1039/c4cs00025k Text en This journal is © The Royal Society of Chemistry 2014 https://creativecommons.org/licenses/by-nc/2.0/uk/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/ (https://creativecommons.org/licenses/by-nc/2.0/uk/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Merino, Estíbaliz Nevado, Cristina Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title | Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title_full | Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title_fullStr | Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title_full_unstemmed | Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title_short | Addition of CF(3) across unsaturated moieties: a powerful functionalization tool |
title_sort | addition of cf(3) across unsaturated moieties: a powerful functionalization tool |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141301/ https://www.ncbi.nlm.nih.gov/pubmed/24789472 http://dx.doi.org/10.1039/c4cs00025k |
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