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Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions
HLA-G and HLA-E are immunoregulatory molecules that belong to HLA-Ib family. The role of these molecules in the control of the immune response has been extensively analyzed, both in physiological and pathological conditions. We have here summarized data present in the literature regarding the intera...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141331/ https://www.ncbi.nlm.nih.gov/pubmed/25202308 http://dx.doi.org/10.3389/fimmu.2014.00394 |
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author | Morandi, Fabio Pistoia, Vito |
author_facet | Morandi, Fabio Pistoia, Vito |
author_sort | Morandi, Fabio |
collection | PubMed |
description | HLA-G and HLA-E are immunoregulatory molecules that belong to HLA-Ib family. The role of these molecules in the control of the immune response has been extensively analyzed, both in physiological and pathological conditions. We have here summarized data present in the literature regarding the interaction of these molecules in different settings. These data suggested that HLA-G and -E co-operate in physiological conditions (i.e., establishment of an immune tolerance at maternal/fetal interface during pregnancy), whereas their role in the course of tumors or autoimmune/inflammatory diseases may be different or even opposite. Future studies aimed at investigating the interaction between HLA-G and HLA-E will help to clarify mechanism(s) underlying the regulation of immune effector cells in health and disease. |
format | Online Article Text |
id | pubmed-4141331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41413312014-09-08 Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions Morandi, Fabio Pistoia, Vito Front Immunol Immunology HLA-G and HLA-E are immunoregulatory molecules that belong to HLA-Ib family. The role of these molecules in the control of the immune response has been extensively analyzed, both in physiological and pathological conditions. We have here summarized data present in the literature regarding the interaction of these molecules in different settings. These data suggested that HLA-G and -E co-operate in physiological conditions (i.e., establishment of an immune tolerance at maternal/fetal interface during pregnancy), whereas their role in the course of tumors or autoimmune/inflammatory diseases may be different or even opposite. Future studies aimed at investigating the interaction between HLA-G and HLA-E will help to clarify mechanism(s) underlying the regulation of immune effector cells in health and disease. Frontiers Media S.A. 2014-08-22 /pmc/articles/PMC4141331/ /pubmed/25202308 http://dx.doi.org/10.3389/fimmu.2014.00394 Text en Copyright © 2014 Morandi and Pistoia. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Morandi, Fabio Pistoia, Vito Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title | Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title_full | Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title_fullStr | Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title_full_unstemmed | Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title_short | Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions |
title_sort | interactions between hla-g and hla-e in physiological and pathological conditions |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141331/ https://www.ncbi.nlm.nih.gov/pubmed/25202308 http://dx.doi.org/10.3389/fimmu.2014.00394 |
work_keys_str_mv | AT morandifabio interactionsbetweenhlagandhlaeinphysiologicalandpathologicalconditions AT pistoiavito interactionsbetweenhlagandhlaeinphysiologicalandpathologicalconditions |