Combined Therapy With GABA and Proinsulin/Alum Acts Synergistically to Restore Long-term Normoglycemia by Modulating T-Cell Autoimmunity and Promoting β-Cell Replication in Newly Diabetic NOD Mice

Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread. We hypothesized that combining a fast-acting anti-inflammatory agent with an ABT could limit pathogenic...

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Detalles Bibliográficos
Autores principales: Tian, Jide, Dang, Hoa, Nguyen, An Viet, Chen, Zheying, Kaufman, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141368/
https://www.ncbi.nlm.nih.gov/pubmed/25146474
http://dx.doi.org/10.2337/db13-1385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141368/
https://www.ncbi.nlm.nih.gov/pubmed/25146474
http://dx.doi.org/10.2337/db13-1385

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