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Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation

Studies from human cells, rats, and zebrafish have documented that hyperglycemia (HG) induces the demethylation of specific cytosines throughout the genome. We previously documented that a subset of these changes become permanent and may provide, in part, a mechanism for the persistence of complicat...

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Detalles Bibliográficos
Autores principales:	Dhliwayo, Nyembezi, Sarras, Michael P., Luczkowski, Ernest, Mason, Samantha M., Intine, Robert V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141369/ https://www.ncbi.nlm.nih.gov/pubmed/24722243 http://dx.doi.org/10.2337/db13-1916

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