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Split Personality of a Potyvirus: To Specialize or Not to Specialize?

Bean yellow mosaic virus (BYMV), genus Potyvirus, has an extensive natural host range encompassing both dicots and monocots. Its phylogenetic groups were considered to consist of an ancestral generalist group and six specialist groups derived from this generalist group during plant domestication. Re...

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Autores principales: Kehoe, Monica A., Coutts, Brenda A., Buirchell, Bevan J., Jones, Roger A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141833/
https://www.ncbi.nlm.nih.gov/pubmed/25148372
http://dx.doi.org/10.1371/journal.pone.0105770
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author Kehoe, Monica A.
Coutts, Brenda A.
Buirchell, Bevan J.
Jones, Roger A. C.
author_facet Kehoe, Monica A.
Coutts, Brenda A.
Buirchell, Bevan J.
Jones, Roger A. C.
author_sort Kehoe, Monica A.
collection PubMed
description Bean yellow mosaic virus (BYMV), genus Potyvirus, has an extensive natural host range encompassing both dicots and monocots. Its phylogenetic groups were considered to consist of an ancestral generalist group and six specialist groups derived from this generalist group during plant domestication. Recombination was suggested to be playing a role in BYMV's evolution towards host specialization. However, in subsequent phylogenetic analysis of whole genomes, group names based on the original hosts of isolates within each of them were no longer supported. Also, nine groups were found and designated I-IX. Recombination analysis was conducted on the complete coding regions of 33 BYMV genomes and two genomes of the related Clover yellow vein virus (CYVV). This analysis found evidence for 12 firm recombination events within BYMV phylogenetic groups I–VI, but none within groups VII–IX or CYVV. The greatest numbers of recombination events within a sequence (two or three each) occurred in four groups, three which formerly constituted the single ancestral generalist group (I, II and IV), and group VI. The individual sequences in groups III and V had one event each. These findings with whole genomes are consistent with recombination being associated with expanding host ranges, and call into question the proposed role of recombination in the evolution of BYMV, where it was previously suggested to play a role in host specialization. Instead, they (i) indicate that recombination explains the very broad natural host ranges of the three BYMV groups which infect both monocots and dicots (I, II, IV), and (ii) suggest that the three groups with narrow natural host ranges (III, V, VI) which also showed recombination now have the potential to reduce host specificity and broaden their natural host ranges.
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spelling pubmed-41418332014-08-25 Split Personality of a Potyvirus: To Specialize or Not to Specialize? Kehoe, Monica A. Coutts, Brenda A. Buirchell, Bevan J. Jones, Roger A. C. PLoS One Research Article Bean yellow mosaic virus (BYMV), genus Potyvirus, has an extensive natural host range encompassing both dicots and monocots. Its phylogenetic groups were considered to consist of an ancestral generalist group and six specialist groups derived from this generalist group during plant domestication. Recombination was suggested to be playing a role in BYMV's evolution towards host specialization. However, in subsequent phylogenetic analysis of whole genomes, group names based on the original hosts of isolates within each of them were no longer supported. Also, nine groups were found and designated I-IX. Recombination analysis was conducted on the complete coding regions of 33 BYMV genomes and two genomes of the related Clover yellow vein virus (CYVV). This analysis found evidence for 12 firm recombination events within BYMV phylogenetic groups I–VI, but none within groups VII–IX or CYVV. The greatest numbers of recombination events within a sequence (two or three each) occurred in four groups, three which formerly constituted the single ancestral generalist group (I, II and IV), and group VI. The individual sequences in groups III and V had one event each. These findings with whole genomes are consistent with recombination being associated with expanding host ranges, and call into question the proposed role of recombination in the evolution of BYMV, where it was previously suggested to play a role in host specialization. Instead, they (i) indicate that recombination explains the very broad natural host ranges of the three BYMV groups which infect both monocots and dicots (I, II, IV), and (ii) suggest that the three groups with narrow natural host ranges (III, V, VI) which also showed recombination now have the potential to reduce host specificity and broaden their natural host ranges. Public Library of Science 2014-08-22 /pmc/articles/PMC4141833/ /pubmed/25148372 http://dx.doi.org/10.1371/journal.pone.0105770 Text en © 2014 Kehoe et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kehoe, Monica A.
Coutts, Brenda A.
Buirchell, Bevan J.
Jones, Roger A. C.
Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title_full Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title_fullStr Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title_full_unstemmed Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title_short Split Personality of a Potyvirus: To Specialize or Not to Specialize?
title_sort split personality of a potyvirus: to specialize or not to specialize?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141833/
https://www.ncbi.nlm.nih.gov/pubmed/25148372
http://dx.doi.org/10.1371/journal.pone.0105770
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