Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Clonally expanded mitochondrial DNA (mtDNA) mutations resulting in focal respiratory chain deficiency in individual cells are proposed to contribute to the ageing of human tissues that depend on adult stem cells for self-renewal; however, the consequences of these mutations remain unclear. A good an...

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Detalles Bibliográficos
Autores principales: Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ireland 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908/
https://www.ncbi.nlm.nih.gov/pubmed/24915468
http://dx.doi.org/10.1016/j.mad.2014.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141908/
https://www.ncbi.nlm.nih.gov/pubmed/24915468
http://dx.doi.org/10.1016/j.mad.2014.06.003

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