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Relationship between gut hormones and glucose homeostasis after bariatric surgery

Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective treatment for severely obese patients. After bariatric surgery, T2D patients have shown a sig...

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Autores principales: Sala, Priscila Campos, Torrinhas, Raquel Susana, Giannella-Neto, Daniel, Waitzberg, Dan Linetzky
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141947/
https://www.ncbi.nlm.nih.gov/pubmed/25152774
http://dx.doi.org/10.1186/1758-5996-6-87
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author Sala, Priscila Campos
Torrinhas, Raquel Susana
Giannella-Neto, Daniel
Waitzberg, Dan Linetzky
author_facet Sala, Priscila Campos
Torrinhas, Raquel Susana
Giannella-Neto, Daniel
Waitzberg, Dan Linetzky
author_sort Sala, Priscila Campos
collection PubMed
description Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective treatment for severely obese patients. After bariatric surgery, T2D patients have shown a significant improvement in glycemic control, even before substantial weight loss and often discontinuation of medication for diabetes control. A central role for enteroendocrine cells from the epithelium of the gastrointestinal tract has been speculated in this postoperative phenomenon. These cells produce and secrete polypeptides - gut hormones - that are associated with regulating energy intake and glucose homeostasis through modulation of peripheral target organs, including the endocrine pancreas. This article reviews and discusses the biological actions of the gut hormones ghrelin, cholecystokinin, incretins, enteroglucagon, and Peptide YY, all of which were recently identified as potential candidates for mediators of glycemic control after bariatric surgery. In conclusion, current data reinforce the hypothesis that T2D reversion after bariatric surgery may be related to glycemic homeostasis developed by the intestine.
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spelling pubmed-41419472014-08-24 Relationship between gut hormones and glucose homeostasis after bariatric surgery Sala, Priscila Campos Torrinhas, Raquel Susana Giannella-Neto, Daniel Waitzberg, Dan Linetzky Diabetol Metab Syndr Review Type 2 diabetes mellitus (T2D) is emerging as a worldwide public health problem, and is mainly associated with an increased incidence of obesity. Bariatric surgery is currently considered the most effective treatment for severely obese patients. After bariatric surgery, T2D patients have shown a significant improvement in glycemic control, even before substantial weight loss and often discontinuation of medication for diabetes control. A central role for enteroendocrine cells from the epithelium of the gastrointestinal tract has been speculated in this postoperative phenomenon. These cells produce and secrete polypeptides - gut hormones - that are associated with regulating energy intake and glucose homeostasis through modulation of peripheral target organs, including the endocrine pancreas. This article reviews and discusses the biological actions of the gut hormones ghrelin, cholecystokinin, incretins, enteroglucagon, and Peptide YY, all of which were recently identified as potential candidates for mediators of glycemic control after bariatric surgery. In conclusion, current data reinforce the hypothesis that T2D reversion after bariatric surgery may be related to glycemic homeostasis developed by the intestine. BioMed Central 2014-08-16 /pmc/articles/PMC4141947/ /pubmed/25152774 http://dx.doi.org/10.1186/1758-5996-6-87 Text en © Sala et al.; licensee BioMed Central Ltd. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Sala, Priscila Campos
Torrinhas, Raquel Susana
Giannella-Neto, Daniel
Waitzberg, Dan Linetzky
Relationship between gut hormones and glucose homeostasis after bariatric surgery
title Relationship between gut hormones and glucose homeostasis after bariatric surgery
title_full Relationship between gut hormones and glucose homeostasis after bariatric surgery
title_fullStr Relationship between gut hormones and glucose homeostasis after bariatric surgery
title_full_unstemmed Relationship between gut hormones and glucose homeostasis after bariatric surgery
title_short Relationship between gut hormones and glucose homeostasis after bariatric surgery
title_sort relationship between gut hormones and glucose homeostasis after bariatric surgery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141947/
https://www.ncbi.nlm.nih.gov/pubmed/25152774
http://dx.doi.org/10.1186/1758-5996-6-87
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