Cargando…

Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study

Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring....

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Harsimrat, Cooper, Robert J., Wai Lee, Chuen, Dempsey, Laura, Edwards, Andrea, Brigadoi, Sabrina, Airantzis, Dimitrios, Everdell, Nick, Michell, Andrew, Holder, David, Hebden, Jeremy C., Austin, Topun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141980/
https://www.ncbi.nlm.nih.gov/pubmed/25161892
http://dx.doi.org/10.1016/j.nicl.2014.06.012
_version_ 1782331724871499776
author Singh, Harsimrat
Cooper, Robert J.
Wai Lee, Chuen
Dempsey, Laura
Edwards, Andrea
Brigadoi, Sabrina
Airantzis, Dimitrios
Everdell, Nick
Michell, Andrew
Holder, David
Hebden, Jeremy C.
Austin, Topun
author_facet Singh, Harsimrat
Cooper, Robert J.
Wai Lee, Chuen
Dempsey, Laura
Edwards, Andrea
Brigadoi, Sabrina
Airantzis, Dimitrios
Everdell, Nick
Michell, Andrew
Holder, David
Hebden, Jeremy C.
Austin, Topun
author_sort Singh, Harsimrat
collection PubMed
description Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring. Interpreting neonatal EEG requires expertise and the impact of seizures on the developing brain remains poorly understood. In this case study we present the first ever images of the haemodynamic impact of seizures on the human infant brain, obtained using simultaneous diffuse optical tomography (DOT) and video-EEG with whole-scalp coverage. Seven discrete periods of ictal electrographic activity were observed during a 60 minute recording of an infant with hypoxic–ischaemic encephalopathy. The resulting DOT images show a remarkably consistent, high-amplitude, biphasic pattern of changes in cortical blood volume and oxygenation in response to each electrographic event. While there is spatial variation across the cortex, the dominant haemodynamic response to seizure activity consists of an initial increase in cortical blood volume prior to a large and extended decrease typically lasting several minutes. This case study demonstrates the wealth of physiologically and clinically relevant information that DOT–EEG techniques can yield. The consistency and scale of the haemodynamic responses observed here also suggest that DOT–EEG has the potential to provide improved detection of neonatal seizures.
format Online
Article
Text
id pubmed-4141980
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-41419802014-08-26 Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study Singh, Harsimrat Cooper, Robert J. Wai Lee, Chuen Dempsey, Laura Edwards, Andrea Brigadoi, Sabrina Airantzis, Dimitrios Everdell, Nick Michell, Andrew Holder, David Hebden, Jeremy C. Austin, Topun Neuroimage Clin Article Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring. Interpreting neonatal EEG requires expertise and the impact of seizures on the developing brain remains poorly understood. In this case study we present the first ever images of the haemodynamic impact of seizures on the human infant brain, obtained using simultaneous diffuse optical tomography (DOT) and video-EEG with whole-scalp coverage. Seven discrete periods of ictal electrographic activity were observed during a 60 minute recording of an infant with hypoxic–ischaemic encephalopathy. The resulting DOT images show a remarkably consistent, high-amplitude, biphasic pattern of changes in cortical blood volume and oxygenation in response to each electrographic event. While there is spatial variation across the cortex, the dominant haemodynamic response to seizure activity consists of an initial increase in cortical blood volume prior to a large and extended decrease typically lasting several minutes. This case study demonstrates the wealth of physiologically and clinically relevant information that DOT–EEG techniques can yield. The consistency and scale of the haemodynamic responses observed here also suggest that DOT–EEG has the potential to provide improved detection of neonatal seizures. Elsevier 2014-07-06 /pmc/articles/PMC4141980/ /pubmed/25161892 http://dx.doi.org/10.1016/j.nicl.2014.06.012 Text en © 2014 The Authors. Published by Elsevier Inc. All rights reserved. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Singh, Harsimrat
Cooper, Robert J.
Wai Lee, Chuen
Dempsey, Laura
Edwards, Andrea
Brigadoi, Sabrina
Airantzis, Dimitrios
Everdell, Nick
Michell, Andrew
Holder, David
Hebden, Jeremy C.
Austin, Topun
Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title_full Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title_fullStr Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title_full_unstemmed Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title_short Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: A case study
title_sort mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: a case study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141980/
https://www.ncbi.nlm.nih.gov/pubmed/25161892
http://dx.doi.org/10.1016/j.nicl.2014.06.012
work_keys_str_mv AT singhharsimrat mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT cooperrobertj mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT waileechuen mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT dempseylaura mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT edwardsandrea mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT brigadoisabrina mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT airantzisdimitrios mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT everdellnick mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT michellandrew mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT holderdavid mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT hebdenjeremyc mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy
AT austintopun mappingcorticalhaemodynamicsduringneonatalseizuresusingdiffuseopticaltomographyacasestudy