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Gossypol Promotes Degeneration of Ovarian Follicles in Rats

The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classifi...

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Autores principales: Gadelha, Ivana Cristina Nunes, Fernandes de Macedo, Michelly, Oloris, Sílvia Catarina Salgado, Melo, Marilia Martins, Soto-Blanco, Benito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142328/
https://www.ncbi.nlm.nih.gov/pubmed/25540815
http://dx.doi.org/10.1155/2014/986184
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author Gadelha, Ivana Cristina Nunes
Fernandes de Macedo, Michelly
Oloris, Sílvia Catarina Salgado
Melo, Marilia Martins
Soto-Blanco, Benito
author_facet Gadelha, Ivana Cristina Nunes
Fernandes de Macedo, Michelly
Oloris, Sílvia Catarina Salgado
Melo, Marilia Martins
Soto-Blanco, Benito
author_sort Gadelha, Ivana Cristina Nunes
collection PubMed
description The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle.
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spelling pubmed-41423282014-12-24 Gossypol Promotes Degeneration of Ovarian Follicles in Rats Gadelha, Ivana Cristina Nunes Fernandes de Macedo, Michelly Oloris, Sílvia Catarina Salgado Melo, Marilia Martins Soto-Blanco, Benito ScientificWorldJournal Research Article The present study aimed to determine if gossypol interferes with ovarian follicles in rats. Twenty-four female Wistar rats were assigned to two equal groups: one control group and the other dosed with gossypol (25 mg/kg/day, subcutaneously) for 15 days. Ovarian follicles were histologically classified according to the stage of development and as normal or atretic. Gossypol treatment reduced the length of estrous with an increase in the duration of the diestrus phase. This compound was responsible for reduced serum levels of T4 and progesterone. Treatment with gossypol was responsible for a significant reduction in the number of normal ovarian follicles and a significant increase in the number of atretic follicles, both in all stages of development. Thus, treatment of rats with gossypol was responsible for reduction in the number of viable follicles and changes in hormone levels that resulted in interference of the estrous cycle. Hindawi Publishing Corporation 2014 2014-07-23 /pmc/articles/PMC4142328/ /pubmed/25540815 http://dx.doi.org/10.1155/2014/986184 Text en Copyright © 2014 Ivana Cristina Nunes Gadelha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gadelha, Ivana Cristina Nunes
Fernandes de Macedo, Michelly
Oloris, Sílvia Catarina Salgado
Melo, Marilia Martins
Soto-Blanco, Benito
Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title_full Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title_fullStr Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title_full_unstemmed Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title_short Gossypol Promotes Degeneration of Ovarian Follicles in Rats
title_sort gossypol promotes degeneration of ovarian follicles in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142328/
https://www.ncbi.nlm.nih.gov/pubmed/25540815
http://dx.doi.org/10.1155/2014/986184
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