ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue

Hypoxia Inducible Factor 1 (HIF-1) promotes fibrosis and inflammation in adipose tissues, while estrogens and Estrogen Receptor α (ERα) have the opposite effect. Here we identify an Estrogen Response Element (ERE) in the promoter of Phd3, which is a negative regulatory enzyme of HIF-1, and we demons...

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Detalles Bibliográficos
Autores principales: Kim, Min, Neinast, Michael D., Frank, Aaron P., Sun, Kai, Park, Jiyoung, Zehr, Jordan A., Vishvanath, Lavanya, Morselli, Eugenia, Amelotte, Mason, Palmer, Biff F., Gupta, Rana K., Scherer, Philipp E., Clegg, Deborah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142394/
https://www.ncbi.nlm.nih.gov/pubmed/25161887
http://dx.doi.org/10.1016/j.molmet.2014.05.007

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