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Hypervolemia for Hypertension Pathophysiology: A Population-Based Study
Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, heig...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142663/ https://www.ncbi.nlm.nih.gov/pubmed/25177700 http://dx.doi.org/10.1155/2014/895401 |
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author | Hür, Ender Özişik, Melih Ural, Cihan Yildiz, Gürsel Mağden, Kemal Budak Köse, Sennur Köktürk, Füruzan Büyükuysal, Çağatay Yildirim, İbrahim Süleymanlar, Gültekin Ateş, Kenan Duman, Soner |
author_facet | Hür, Ender Özişik, Melih Ural, Cihan Yildiz, Gürsel Mağden, Kemal Budak Köse, Sennur Köktürk, Füruzan Büyükuysal, Çağatay Yildirim, İbrahim Süleymanlar, Gültekin Ateş, Kenan Duman, Soner |
author_sort | Hür, Ender |
collection | PubMed |
description | Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18–89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6 mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8–50.6) kg/m(2); overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension. |
format | Online Article Text |
id | pubmed-4142663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41426632014-08-31 Hypervolemia for Hypertension Pathophysiology: A Population-Based Study Hür, Ender Özişik, Melih Ural, Cihan Yildiz, Gürsel Mağden, Kemal Budak Köse, Sennur Köktürk, Füruzan Büyükuysal, Çağatay Yildirim, İbrahim Süleymanlar, Gültekin Ateş, Kenan Duman, Soner Biomed Res Int Research Article Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18–89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6 mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8–50.6) kg/m(2); overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension. Hindawi Publishing Corporation 2014 2014-08-11 /pmc/articles/PMC4142663/ /pubmed/25177700 http://dx.doi.org/10.1155/2014/895401 Text en Copyright © 2014 Ender Hür et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hür, Ender Özişik, Melih Ural, Cihan Yildiz, Gürsel Mağden, Kemal Budak Köse, Sennur Köktürk, Füruzan Büyükuysal, Çağatay Yildirim, İbrahim Süleymanlar, Gültekin Ateş, Kenan Duman, Soner Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title | Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title_full | Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title_fullStr | Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title_full_unstemmed | Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title_short | Hypervolemia for Hypertension Pathophysiology: A Population-Based Study |
title_sort | hypervolemia for hypertension pathophysiology: a population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142663/ https://www.ncbi.nlm.nih.gov/pubmed/25177700 http://dx.doi.org/10.1155/2014/895401 |
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