Cargando…

Age-dependent pattern of cerebellar susceptibility to bilirubin neurotoxicity in vivo in mice

Neonatal jaundice is caused by high levels of unconjugated bilirubin. It is usually a temporary condition caused by delayed induction of UGT1A1, which conjugates bilirubin in the liver. To reduce bilirubin levels, affected babies are exposed to phototherapy (PT), which converts toxic bilirubin into...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bortolussi, Giulia, Baj, Gabriele, Vodret, Simone, Viviani, Giulia, Bittolo, Tamara, Muro, Andrés F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142726/ https://www.ncbi.nlm.nih.gov/pubmed/25062689 http://dx.doi.org/10.1242/dmm.016535

Ejemplares similares

Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1(-/-) mouse model
por: Vodret, Simone, et al.
Publicado: (2017)

Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer
por: Bortolussi, Giulia, et al.
Publicado: (2012)

Activation of Alternative Bilirubin Clearance Pathways Partially Reduces Hyperbilirubinemia in a Mouse Model Lacking Functional Ugt1a1 Activity
por: Banerjee, Bhaswati, et al.
Publicado: (2022)

Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells
por: Rawat, Vipin, et al.
Publicado: (2018)

Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice
por: Bortolussi, G, et al.
Publicado: (2015)

Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia
por: Vodret, Simone, et al.
Publicado: (2015)

Promoterless gene targeting without nucleases rescues lethality of a Crigler‐Najjar syndrome mouse model
por: Porro, Fabiola, et al.
Publicado: (2017)

The use of transcutaneous bilirubin nomograms for the prevention of bilirubin neurotoxicity in the neonates
por: Casnocha Lucanova, Lucia, et al.
Publicado: (2023)

Bilirubin neurotoxicity is associated with proteasome inhibition
por: Huang, Hongbiao, et al.
Publicado: (2017)

Bilirubin-induced neurotoxicity and visuocortical dysfunction
por: Good, William V., et al.
Publicado: (2022)

Bilirubin Neurotoxicity in Preterm Infants: Risk and Prevention
por: Bhutani, Vinod K., et al.
Publicado: (2013)

Neurotoxicity of Unconjugated Bilirubin in Neonatal Hypoxic-Ischemic Brain Injury in vitro
por: Dani, Carlo, et al.
Publicado: (2021)

Microglia Susceptibility to Free Bilirubin Is Age-Dependent
por: Vaz, Ana Rita, et al.
Publicado: (2020)

Serum Bilirubin Levels and Promoter Variations in HMOX1 and UGT1A1 Genes in Patients with Fabry Disease
por: Jirásková, Alena, et al.
Publicado: (2017)

Ca(2+)-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity
por: Shi, Hao-Song, et al.
Publicado: (2019)

The Evolving Landscape of Neurotoxicity by Unconjugated Bilirubin: Role of Glial Cells and Inflammation
por: Brites, Dora
Publicado: (2012)

Generation of Ugt1-Deficient Murine Liver Cell Lines Using TALEN Technology
por: Porro, Fabiola, et al.
Publicado: (2014)

Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice
por: Bittolo, Tamara, et al.
Publicado: (2016)

Low efficacy of recombinant SV40 in Ugt1a1(-/-) mice with severe inherited hyperbilirubinemia
por: Shi, Xiaoxia, et al.
Publicado: (2021)

Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1(−/−) Mice: Impact on Redox Status and Metabolism
por: Bortolussi, Giulia, et al.
Publicado: (2021)

Morphohistometric analysis of the effects of Coriandrum sativum on cortical and cerebellar neurotoxicity
por: Mustafa, Hesham N.
Publicado: (2021)

Comparison of discrimination and calibration performance of ECG-based machine learning models for prediction of new-onset atrial fibrillation
por: Baj, Giovanni, et al.
Publicado: (2023)

Bilirubin inhibits lipid raft dependent functions of L1 cell adhesion molecule in rat pup cerebellar granule neurons
por: Kitchen, Spencer T., et al.
Publicado: (2021)

Choline supplementation prevents the effects of bilirubin on cerebellar mediated behavior in choline-restricted Gunn rat pups.
por: Waddell, Jaylyn, et al.
Publicado: (2020)

In vivo evidence of exosome-mediated Aβ neurotoxicity
por: Elsherbini, Ahmed, et al.
Publicado: (2020)

Genetic susceptibility to methylmercury developmental neurotoxicity matters
por: Julvez, Jordi, et al.
Publicado: (2013)

Calcium Supplementation Ameliorates Cerebellar Oxidative Stress in Lactational Aluminum-induced Neurotoxicity in Rats
por: Omotoso, Gabriel Olaiya, et al.
Publicado: (2022)

Neurotoxicity of Acrylamide in Exposed Workers
por: Pennisi, Manuela, et al.
Publicado: (2013)

Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance
por: Chen, Weiyu, et al.
Publicado: (2021)

Coating-Dependent Neurotoxicity of Silver Nanoparticles—An In Vivo Study on Hippocampal Oxidative Stress and Neurosteroids
por: Dziendzikowska, Katarzyna, et al.
Publicado: (2022)

Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo
por: Dhar, Matasha, et al.
Publicado: (2018)

Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity
por: Sur, Malinki, et al.
Publicado: (2018)

The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects
por: Lambert, Erwan, et al.
Publicado: (2022)

Brain susceptibility imaging provides valuable in vivo insights into cerebellar diseases, but biological interpretations remain elusive
por: Harding, Ian H., et al.
Publicado: (2022)

In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers
por: Simoneau, Steve, et al.
Publicado: (2007)

Editorial: Sex and Gene-Dependent Neurotoxicity
por: Ruszkiewicz, Joanna A., et al.
Publicado: (2019)

Bilirubin/Albumin Ratio for Predicting Acute Bilirubin-induced Neurologic Dysfunction
por: Ardakani, Shahin Behjati, et al.
Publicado: (2011)

The inherited cerebellar ataxias: an update
por: Coarelli, Giulia, et al.
Publicado: (2022)

THE RENAL ELIMINATION OF BILIRUBIN
por: Haessler, Herbert, et al.
Publicado: (1922)

Bilirubin and Endothelial Function
por: Maruhashi, Tatsuya, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_3rr5sh5nkr4ovkm6t9ifqgs2uv