Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-α deficiency

Glycogen storage disease type 1a (GSD-1a) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α), and is characterized by impaired glucose homeostasis and a high risk of developing hepatocellular adenomas (HCAs). A globally G6Pase-α-deficient (G6pc(−/−)) mouse model that shows pathological...

Descripción completa

Detalles Bibliográficos
Autores principales: Resaz, Roberta, Vanni, Cristina, Segalerba, Daniela, Sementa, Angela R., Mastracci, Luca, Grillo, Federica, Murgia, Daniele, Bosco, Maria Carla, Chou, Janice Y., Barbieri, Ottavia, Varesio, Luigi, Eva, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142728/
https://www.ncbi.nlm.nih.gov/pubmed/25147298
http://dx.doi.org/10.1242/dmm.014878

Ejemplares similares

Ejemplares similares