Synthesis of isoprenoid bisphosphonate ethers through C–P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase

A set of bisphosphonate ethers has been prepared through sequential phosphonylation and alkylation of monophosphonate ethers. After formation of the corresponding phosphonic acid salts, these compounds were tested for their ability to inhibit the enzyme geranylgeranyl diphosphate synthase (GGDPS). F...

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Detalles Bibliográficos
Autores principales: Zhou, Xiang, Reilly, Jacqueline E, Loerch, Kathleen A, Hohl, Raymond J, Wiemer, David F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142842/
https://www.ncbi.nlm.nih.gov/pubmed/25161722
http://dx.doi.org/10.3762/bjoc.10.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142842/
https://www.ncbi.nlm.nih.gov/pubmed/25161722
http://dx.doi.org/10.3762/bjoc.10.171

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