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The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases

Two approaches to the synthesis of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (1, clofarabine) were studied. The first approach consists in the chemical synthesis of 2-deoxy-2-fluoro-α-D-arabinofuranose-1-phosphate (12a, (2F)Ara-1P) via three step conversion of 1,3,5-tri-O-benzoyl-2-d...

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Detalles Bibliográficos
Autores principales:	Fateev, Ilja V, Antonov, Konstantin V, Konstantinova, Irina D, Muravyova, Tatyana I, Seela, Frank, Esipov, Roman S, Miroshnikov, Anatoly I, Mikhailopulo, Igor A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2014
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142866/ https://www.ncbi.nlm.nih.gov/pubmed/25161724 http://dx.doi.org/10.3762/bjoc.10.173

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