Postsynthetic functionalization of glycodendrons at the focal point

Glycodendrons are multivalent glycoconjugates bearing an orthogonal functional group at the focal point of the molecule. This allows for their postsynthetic elaboration to achieve amphiphilic glycolipid mimetics, for example, which eventually can be applied in biology, biophysics, or material scienc...

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Detalles Bibliográficos
Autores principales: Lindhorst, Thisbe K, Elsner, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2014
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142895/
https://www.ncbi.nlm.nih.gov/pubmed/25161704
http://dx.doi.org/10.3762/bjoc.10.152
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author Lindhorst, Thisbe K
Elsner, Katharina
author_facet Lindhorst, Thisbe K
Elsner, Katharina
author_sort Lindhorst, Thisbe K
collection PubMed
description Glycodendrons are multivalent glycoconjugates bearing an orthogonal functional group at the focal point of the molecule. This allows for their postsynthetic elaboration to achieve amphiphilic glycolipid mimetics, for example, which eventually can be applied in biology, biophysics, or material science. Here, postsynthetic modification of di- and tetravalent polyether glycodendrons has been explored using etherification, thiol-ene reaction and in particular olefin cross metathesis.
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spelling pubmed-41428952014-08-26 Postsynthetic functionalization of glycodendrons at the focal point Lindhorst, Thisbe K Elsner, Katharina Beilstein J Org Chem Full Research Paper Glycodendrons are multivalent glycoconjugates bearing an orthogonal functional group at the focal point of the molecule. This allows for their postsynthetic elaboration to achieve amphiphilic glycolipid mimetics, for example, which eventually can be applied in biology, biophysics, or material science. Here, postsynthetic modification of di- and tetravalent polyether glycodendrons has been explored using etherification, thiol-ene reaction and in particular olefin cross metathesis. Beilstein-Institut 2014-07-01 /pmc/articles/PMC4142895/ /pubmed/25161704 http://dx.doi.org/10.3762/bjoc.10.152 Text en Copyright © 2014, Lindhorst and Elsner https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Lindhorst, Thisbe K
Elsner, Katharina
Postsynthetic functionalization of glycodendrons at the focal point
title Postsynthetic functionalization of glycodendrons at the focal point
title_full Postsynthetic functionalization of glycodendrons at the focal point
title_fullStr Postsynthetic functionalization of glycodendrons at the focal point
title_full_unstemmed Postsynthetic functionalization of glycodendrons at the focal point
title_short Postsynthetic functionalization of glycodendrons at the focal point
title_sort postsynthetic functionalization of glycodendrons at the focal point
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142895/
https://www.ncbi.nlm.nih.gov/pubmed/25161704
http://dx.doi.org/10.3762/bjoc.10.152
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