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Could Cancer Initiate From Bone Marrow Progenitors?
BACKGROUND: Defining cancer stem cells and their origins is of much controversy,and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein,we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cancer Research Center, Shahid Beheshti University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142913/ https://www.ncbi.nlm.nih.gov/pubmed/25250119 |
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author | Ben Nasr, Hmed Hammami, Serria Turky Zeghal, Khaled |
author_facet | Ben Nasr, Hmed Hammami, Serria Turky Zeghal, Khaled |
author_sort | Ben Nasr, Hmed |
collection | PubMed |
description | BACKGROUND: Defining cancer stem cells and their origins is of much controversy,and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein,we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program - the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients. |
format | Online Article Text |
id | pubmed-4142913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Cancer Research Center, Shahid Beheshti University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-41429132014-09-23 Could Cancer Initiate From Bone Marrow Progenitors? Ben Nasr, Hmed Hammami, Serria Turky Zeghal, Khaled Iran J Cancer Prev Review Article BACKGROUND: Defining cancer stem cells and their origins is of much controversy,and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein,we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program - the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients. Cancer Research Center, Shahid Beheshti University of Medical Sciences 2013 /pmc/articles/PMC4142913/ /pubmed/25250119 Text en © 2014 Cancer Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Review Article Ben Nasr, Hmed Hammami, Serria Turky Zeghal, Khaled Could Cancer Initiate From Bone Marrow Progenitors? |
title | Could Cancer Initiate From Bone Marrow Progenitors? |
title_full | Could Cancer Initiate From Bone Marrow Progenitors? |
title_fullStr | Could Cancer Initiate From Bone Marrow Progenitors? |
title_full_unstemmed | Could Cancer Initiate From Bone Marrow Progenitors? |
title_short | Could Cancer Initiate From Bone Marrow Progenitors? |
title_sort | could cancer initiate from bone marrow progenitors? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142913/ https://www.ncbi.nlm.nih.gov/pubmed/25250119 |
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