The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer

Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide.Genetic background is thought to play a role in modulating individual risks of this cancer.Many stu...

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Autores principales: Rezaei-Tavirani, Mostafa, Safaei, Akram, Zali, Mohammad Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Research Center, Shahid Beheshti University of Medical Sciences 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142938/
https://www.ncbi.nlm.nih.gov/pubmed/25250132
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author Rezaei-Tavirani, Mostafa
Safaei, Akram
Zali, Mohammad Reza
author_facet Rezaei-Tavirani, Mostafa
Safaei, Akram
Zali, Mohammad Reza
author_sort Rezaei-Tavirani, Mostafa
collection PubMed
description Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide.Genetic background is thought to play a role in modulating individual risks of this cancer.Many studies support an association between insulin pathway gene polymorphisms and regulation of tumor cell biology in colorectal cancer. This review examines the role of polymorphisms of insulin and obesity pathway genes (IGFs, INS, INSR, ADIPOQ, ADIPOQR, LEP and LEPR) in development of colorectal cancer.
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spelling pubmed-41429382014-09-23 The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer Rezaei-Tavirani, Mostafa Safaei, Akram Zali, Mohammad Reza Iran J Cancer Prev Review Article Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide.Genetic background is thought to play a role in modulating individual risks of this cancer.Many studies support an association between insulin pathway gene polymorphisms and regulation of tumor cell biology in colorectal cancer. This review examines the role of polymorphisms of insulin and obesity pathway genes (IGFs, INS, INSR, ADIPOQ, ADIPOQR, LEP and LEPR) in development of colorectal cancer. Cancer Research Center, Shahid Beheshti University of Medical Sciences 2013 /pmc/articles/PMC4142938/ /pubmed/25250132 Text en © 2014 Cancer Research Center, Shahid Beheshti University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Review Article
Rezaei-Tavirani, Mostafa
Safaei, Akram
Zali, Mohammad Reza
The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title_full The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title_fullStr The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title_full_unstemmed The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title_short The Association between Polymorphismsin Insulin and Obesity Related Genesand Risk of Colorectal Cancer
title_sort association between polymorphismsin insulin and obesity related genesand risk of colorectal cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142938/
https://www.ncbi.nlm.nih.gov/pubmed/25250132
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