A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75(NTR)). Thus, modulating p75(NTR) signaling is considered a pr...

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Detalles Bibliográficos
Autores principales: Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143160/
https://www.ncbi.nlm.nih.gov/pubmed/25153701
http://dx.doi.org/10.1371/journal.pone.0102136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143160/
https://www.ncbi.nlm.nih.gov/pubmed/25153701
http://dx.doi.org/10.1371/journal.pone.0102136

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