Cargando…

A Small Molecule p75(NTR) Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

Degeneration of basal forebrain cholinergic neurons contributes significantly to the cognitive deficits associated with Alzheimer's disease (AD) and has been attributed to aberrant signaling through the neurotrophin receptor p75 (p75(NTR)). Thus, modulating p75(NTR) signaling is considered a pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simmons, Danielle A., Knowles, Juliet K., Belichenko, Nadia P., Banerjee, Gargi, Finkle, Carly, Massa, Stephen M., Longo, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143160/ https://www.ncbi.nlm.nih.gov/pubmed/25153701 http://dx.doi.org/10.1371/journal.pone.0102136

Ejemplares similares

TSPO–PET imaging using [(18)F]PBR06 is a potential translatable biomarker for treatment response in Huntington’s disease: preclinical evidence with the p75(NTR) ligand LM11A-31
por: Simmons, Danielle A, et al.
Publicado: (2018)

A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer’s mouse model
por: Knowles, Juliet K., et al.
Publicado: (2013)

Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington’s Disease: Preclinical Evidence with the p75(NTR) Ligand LM11A-31
por: Simmons, Danielle A., et al.
Publicado: (2021)

A small molecule p75(NTR) ligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice
por: Simmons, Danielle A., et al.
Publicado: (2016)

Cholinergic neurodegeneration and cholesterol metabolism dysregulation by constitutive p75(NTR) signaling in the p75(exonIII)-KO mice
por: Comaposada-Baró, Raquel, et al.
Publicado: (2023)

p75(NTR) in Huntington's disease: beyond the basal ganglia
por: Brito, Verónica, et al.
Publicado: (2015)

Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR
por: Dasgupta, Srestha, et al.
Publicado: (2023)

Small Molecule, Non-Peptide p75(NTR) Ligands Inhibit Aβ-Induced Neurodegeneration and Synaptic Impairment
por: Yang, Tao, et al.
Publicado: (2008)

Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats
por: Fortress, Ashley M., et al.
Publicado: (2011)

ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75(NTR)-dependent mechanism
por: Howard, Laura, et al.
Publicado: (2013)

The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells
por: Zhao, Manzhu, et al.
Publicado: (2020)

Impaired striatal function in Huntington's disease is due to aberrant p75NTR signaling
por: Plotkin, Joshua L, et al.
Publicado: (2014)

Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus
por: Poser, Robert, et al.
Publicado: (2015)

Structural Characterization of the Self-Association of the Death Domain of p75(NTR)
por: Qu, Qianhui, et al.
Publicado: (2013)

Overexpression of p75(NTR) in Human Seminoma: A New Biomarker?
por: Perri, Anna, et al.
Publicado: (2021)

Commentary: Impact of a deletion of the full-length and short isoform of p75NTR on cholinergic innervation and the population of postmitotic doublecortin positive cells in the dentate gyrus
por: Sabry, Mohamed A., et al.
Publicado: (2016)

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies
por: Brito, V, et al.
Publicado: (2013)

The Nerve Growth Factor Receptor (NGFR/p75(NTR)): A Major Player in Alzheimer’s Disease
por: Bruno, Francesco, et al.
Publicado: (2023)

Glucose homeostasis and p75(NTR): The sweet side of neurotrophin receptor signaling
por: Baeza-Raja, Bernat, et al.
Publicado: (2012)

p75(NTR), but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
por: VonDran, Melissa W., et al.
Publicado: (2014)

Deletion of p75(NTR) rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer’s disease
por: Demuth, Hendrik, et al.
Publicado: (2023)

Rabies Virus Hijacks and Accelerates the p75NTR Retrograde Axonal Transport Machinery
por: Gluska, Shani, et al.
Publicado: (2014)

Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer
por: Yamaguchi, Tetsuji, et al.
Publicado: (2016)

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells
por: Bandoła, Joanna, et al.
Publicado: (2017)

Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression
por: Gonçalves, Nádia P., et al.
Publicado: (2019)

SorCS3 promotes the internalization of p75(NTR) to inhibit GBM progression
por: Zhang, Yanqiu, et al.
Publicado: (2022)

The Effect of Interaction NGF/p75(NTR) in Sperm Cells: A Rabbit Model
por: Castellini, Cesare, et al.
Publicado: (2022)

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease
por: Yao, X-Q, et al.
Publicado: (2015)

Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker
por: Jiao, S-S, et al.
Publicado: (2015)

[(18)F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease
por: James, Michelle L., et al.
Publicado: (2017)

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells
por: Pham, Dan Duc, et al.
Publicado: (2019)

Molecular Mechanism of Switching of TrkA/p75(NTR) Signaling in Monocrotophos Induced Neurotoxicity
por: Kumar, Vivek, et al.
Publicado: (2015)

p75(NTR) antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa
por: Platón-Corchado, María, et al.
Publicado: (2017)

Sexual Dimorphism in Balance and Coordination in p75NTR(exonIII) Knock-Out Mice
por: Abbasian, Mahdi, et al.
Publicado: (2022)

Expression of NGF/proNGF and Their Receptors TrkA, p75(NTR) and Sortilin in Melanoma
por: Marsland, Mark, et al.
Publicado: (2022)

Association of the p75(NTR) Ser205Leu Polymorphism with Asymptomatic HTLV-1 Infection
por: Queiroz, Maria Alice Freitas, et al.
Publicado: (2022)

p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
por: Xie, Bo, et al.
Publicado: (2023)

Tissue-Specificity of Antibodies Raised Against TrkB and p75(NTR) Receptors; Implications for Platelets as Models of Neurodegenerative Diseases
por: Fleury, Samuel, et al.
Publicado: (2021)

Glioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)/CD271) requires regulated interaction with PDLIM1
por: Ahn, B Y, et al.
Publicado: (2016)

Computational Studies of Beta Amyloid (Aβ42) with p75NTR Receptor: A Novel Therapeutic Target in Alzheimer's Disease
por: Devarajan, Shine, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_nm7oltpunep44hs8l5uijh1c9r