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Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer

Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet, recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing...

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Detalles Bibliográficos
Autores principales:	Guerrero-Preston, Rafael, Michailidi, Christina, Marchionni, Luigi, Pickering, Curtis R, Frederick, Mitchell J, Myers, Jeffrey N, Yegnasubramanian, Srinivasan, Hadar, Tal, Noordhuis, Maartje G, Zizkova, Veronika, Fertig, Elana, Agrawal, Nishant, Westra, William, Koch, Wayne, Califano, Joseph, Velculescu, Victor E, Sidransky, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143405/ https://www.ncbi.nlm.nih.gov/pubmed/24786473 http://dx.doi.org/10.4161/epi.29025

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