De novo transcriptome sequencing and digital gene expression analysis predict biosynthetic pathway of rhynchophylline and isorhynchophylline from Uncaria rhynchophylla, a non-model plant with potent anti-alzheimer’s properties

BACKGROUND: The major medicinal alkaloids isolated from Uncaria rhynchophylla (gouteng in chinese) capsules are rhynchophylline (RIN) and isorhynchophylline (IRN). Extracts containing these terpene indole alkaloids (TIAs) can inhibit the formation and destabilize preformed fibrils of amyloid β prote...

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Detalles Bibliográficos
Autores principales: Guo, Qianqian, Ma, Xiaojun, Wei, Shugen, Qiu, Deyou, Wilson, Iain W, Wu, Peng, Tang, Qi, Liu, Lijun, Dong, Shoukun, Zu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143583/
https://www.ncbi.nlm.nih.gov/pubmed/25112168
http://dx.doi.org/10.1186/1471-2164-15-676

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