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Phase I dose-escalation study of the HSP90 inhibitor AUY922 in Japanese patients with advanced solid tumors

PURPOSE: AUY922 is a potent non-geldanamycin inhibitor of heat-shock protein 90. This study was carried out in Japanese patients to determine the maximum tolerated dose (MTD), and to characterize safety, tolerability and pharmacokinetics of single-agent AUY922. METHODS: Japanese patients with advanc...

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Detalles Bibliográficos
Autores principales:	Doi, Toshihiko, Onozawa, Yusuke, Fuse, Nozomu, Yoshino, Takayuki, Yamazaki, Kentaro, Watanabe, Junichiro, Akimov, Mikhail, Robson, Matthew, Boku, Narikazu, Ohtsu, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2014
Materias:	Clinical Trial Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143601/ https://www.ncbi.nlm.nih.gov/pubmed/25059319 http://dx.doi.org/10.1007/s00280-014-2521-x

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