Cargando…

Family-based association test using normal approximation to gene dropping null distribution

We derive the analytical mean and variance of the score test statistic in gene-dropping simulations and approximate the null distribution of the test statistic by a normal distribution. We provide insights into the gene-dropping test by decomposing the test statistic into two components: the first c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Yuan, Emerson, Sarah, Wang, Lu, Li, Lujing, Di, Yanming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Proceedings
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143692/ https://www.ncbi.nlm.nih.gov/pubmed/25519313 http://dx.doi.org/10.1186/1753-6561-8-S1-S18

Ejemplares similares

The null distribution of stochastic search gene suggestion: a Bayesian approach to gene mapping
por: Swartz, Michael D, et al.
Publicado: (2007)

Statistics for approximate gene clusters
por: Jahn, Katharina, et al.
Publicado: (2013)

Approximating the edit distance for genomes with duplicate genes under DCJ, insertion and deletion
por: Shao, Mingfu, et al.
Publicado: (2012)

Power of association tests in the presence of multiple causal variants
por: Di, Yanming, et al.
Publicado: (2011)

Approximating the double-cut-and-join distance between unsigned genomes
por: Chen, Xin, et al.
Publicado: (2011)

Comparative genome analysis of PHB gene family reveals deep evolutionary origins and diverse gene function
por: Di, Chao, et al.
Publicado: (2010)

Type I error rates of rare single nucleotide variants are inflated in tests of association with non–normally distributed traits using simple linear regression methods
por: Schwantes-An, Tae-Hwi, et al.
Publicado: (2016)

Familial aggregation analysis of gene expressions
por: Rao, Shao-Qi, et al.
Publicado: (2007)

Genomic screening in family-based association testing
por: Murphy, Amy, et al.
Publicado: (2005)

Susceptibility scoring in family-based association testing
por: Poisson, Laila M, et al.
Publicado: (2003)

Strategy and model building in the fourth dimension: a null model for genotype × age interaction as a Gaussian stationary stochastic process
por: Diego, Vincent P, et al.
Publicado: (2003)

Asymptotic behaviour and optimal word size for exact and approximate word matches between random sequences
por: Forêt, Sylvain, et al.
Publicado: (2006)

Independent test assessment using the extreme value distribution theory
por: Almeida, Marcio, et al.
Publicado: (2016)

On different approximations to multilocus identity-by-descent calculations and the resulting power of variance component-based linkage analysis
por: Göring, Harald HH, et al.
Publicado: (2003)

Adjustment of familial relatedness in association test for rare variants
por: Li, Cong, et al.
Publicado: (2014)

Testing rare variants for hypertension using family-based tests with different weighting schemes
por: Wang, Xuexia, et al.
Publicado: (2016)

Impact of normalization and filtering on linkage analysis of gene expression data
por: Beyene, Joseph, et al.
Publicado: (2007)

A new transmission test for affected sib-pair families
por: Xu, Hongyan, et al.
Publicado: (2007)

Application of family-based tests of association for rare variants to pathways
por: Greco, Brian, et al.
Publicado: (2014)

Powerful association test combining rare variant and gene expression using family data from Genetic Analysis Workshop 19
por: Ho, Yen-Yi, et al.
Publicado: (2016)

Genome-wide association tests by using block information in family data
por: Tang, Rui, et al.
Publicado: (2007)

Comparing family-based rare variant association tests for dichotomous phenotypes
por: Wang, Longfei, et al.
Publicado: (2016)

Different normalization strategies for microarray gene expression traits affect the heritability estimation
por: Ma, Jun, et al.
Publicado: (2007)

Databases of homologous gene families for comparative genomics
por: Penel, Simon, et al.
Publicado: (2009)

Origin and evolution of gene families in Bacteria and Archaea
por: Collins, R Eric, et al.
Publicado: (2011)

Gene family assignment-free comparative genomics
por: Doerr, Daniel, et al.
Publicado: (2012)

Linkage, case-control association, and family-based association tests for complex disorders
por: Suarez, Brian K, et al.
Publicado: (2007)

Extended T(2 )tests for longitudinal family data in whole genome sequencing studies
por: Liu, Yiwei, et al.
Publicado: (2014)

The genetics of gene expression: comparison of linkage scans using two phenotype normalization methods
por: de Andrade, Mariza, et al.
Publicado: (2007)

Testing for treatment effects on gene ontology
por: Lee, Taewon, et al.
Publicado: (2008)

A new family-based association test via a least-squares method
por: Yang, Song, et al.
Publicado: (2005)

Robust trend tests for genetic association in case-control studies using family data
por: Tian, Xin, et al.
Publicado: (2005)

Family-based tests applied to extended pedigrees identify rare variants related to hypertension
por: Xu, Mengyuan, et al.
Publicado: (2014)

A combined association test for rare variants using family and case-control data
por: Lin, Peng-Lin, et al.
Publicado: (2016)

Testing gene-environment interactions in gene-based association studies
por: Wang, Xuefeng, et al.
Publicado: (2011)

Comparative genome analysis of lignin biosynthesis gene families across the plant kingdom
por: Xu, Zhanyou, et al.
Publicado: (2009)

Genome-wide association tests by two-stage approaches with unified analysis of families and unrelated individuals
por: Wang, Xuexia, et al.
Publicado: (2007)

Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals
por: Lewinger, Juan Pablo, et al.
Publicado: (2005)

An adaptive gene-based test for methylation data
por: Wu, Chong, et al.
Publicado: (2018)

Normalizing a large number of quantitative traits using empirical normal quantile transformation
por: Peng, Bo, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_vm9nriosjqtbksujq46d2jpbf2