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Estimating and adjusting for ancestry admixture in statistical methods for relatedness inference, heritability estimation, and association testing
It is well known that genetic association studies are not robust to population stratification. Two widely used approaches for the detection and correction of population structure are principal component analysis and model-based estimation of ancestry. These methods have been shown to give reliable i...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143704/ https://www.ncbi.nlm.nih.gov/pubmed/25519330 http://dx.doi.org/10.1186/1753-6561-8-S1-S5 |