Haplotype approach for association analysis on hypertension

We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on...

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Autores principales: Shen, Xiaowei, Espin-Garcia, Osvaldo, Qiu, Xin, Brhane, Yonathan, Liu, Geoffrey, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143719/
https://www.ncbi.nlm.nih.gov/pubmed/25519392
http://dx.doi.org/10.1186/1753-6561-8-S1-S57
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author Shen, Xiaowei
Espin-Garcia, Osvaldo
Qiu, Xin
Brhane, Yonathan
Liu, Geoffrey
Xu, Wei
author_facet Shen, Xiaowei
Espin-Garcia, Osvaldo
Qiu, Xin
Brhane, Yonathan
Liu, Geoffrey
Xu, Wei
author_sort Shen, Xiaowei
collection PubMed
description We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also conducted for the whole chromosome 3. We found 1 block from the ULK4 gene and 2 blocks from the LOC64690 gene that were significantly associated with hypertension.
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spelling pubmed-41437192014-09-02 Haplotype approach for association analysis on hypertension Shen, Xiaowei Espin-Garcia, Osvaldo Qiu, Xin Brhane, Yonathan Liu, Geoffrey Xu, Wei BMC Proc Proceedings We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also conducted for the whole chromosome 3. We found 1 block from the ULK4 gene and 2 blocks from the LOC64690 gene that were significantly associated with hypertension. BioMed Central 2014-06-17 /pmc/articles/PMC4143719/ /pubmed/25519392 http://dx.doi.org/10.1186/1753-6561-8-S1-S57 Text en Copyright © 2014 Shen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Proceedings
Shen, Xiaowei
Espin-Garcia, Osvaldo
Qiu, Xin
Brhane, Yonathan
Liu, Geoffrey
Xu, Wei
Haplotype approach for association analysis on hypertension
title Haplotype approach for association analysis on hypertension
title_full Haplotype approach for association analysis on hypertension
title_fullStr Haplotype approach for association analysis on hypertension
title_full_unstemmed Haplotype approach for association analysis on hypertension
title_short Haplotype approach for association analysis on hypertension
title_sort haplotype approach for association analysis on hypertension
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143719/
https://www.ncbi.nlm.nih.gov/pubmed/25519392
http://dx.doi.org/10.1186/1753-6561-8-S1-S57
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AT brhaneyonathan haplotypeapproachforassociationanalysisonhypertension
AT liugeoffrey haplotypeapproachforassociationanalysisonhypertension
AT xuwei haplotypeapproachforassociationanalysisonhypertension

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