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Methadone induces testosterone suppression in patients with opioid addiction

Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how...

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Autores principales: Bawor, Monica, Dennis, Brittany B., Samaan, M. Constantine, Plater, Carolyn, Worster, Andrew, Varenbut, Michael, Daiter, Jeff, Marsh, David C., Desai, Dipika, Steiner, Meir, Anglin, Rebecca, Coote, Margaret, Pare, Guillaume, Thabane, Lehana, Samaan, Zainab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143768/
https://www.ncbi.nlm.nih.gov/pubmed/25155550
http://dx.doi.org/10.1038/srep06189
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author Bawor, Monica
Dennis, Brittany B.
Samaan, M. Constantine
Plater, Carolyn
Worster, Andrew
Varenbut, Michael
Daiter, Jeff
Marsh, David C.
Desai, Dipika
Steiner, Meir
Anglin, Rebecca
Coote, Margaret
Pare, Guillaume
Thabane, Lehana
Samaan, Zainab
author_facet Bawor, Monica
Dennis, Brittany B.
Samaan, M. Constantine
Plater, Carolyn
Worster, Andrew
Varenbut, Michael
Daiter, Jeff
Marsh, David C.
Desai, Dipika
Steiner, Meir
Anglin, Rebecca
Coote, Margaret
Pare, Guillaume
Thabane, Lehana
Samaan, Zainab
author_sort Bawor, Monica
collection PubMed
description Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to methadone treatment for opioid dependence is unclear. The present multi-centre cross-sectional study consecutively recruited 231 patients with opioid dependence from methadone clinics across Ontario, Canada between June and December of 2011. We obtained demographic details, substance use, psychiatric history, and blood and urine samples from enrolled subjects. The control group included 783 non-opioid using adults recruited from a primary care setting in Ontario, Canada. Average testosterone level in men receiving methadone treatment was significantly lower than controls. No effect of opioids including methadone on testosterone level in women was found and testosterone did not fluctuate significantly between menstrual cycle phases. In methadone patients, testosterone level was significantly associated with methadone dose in men only. We recommend that testosterone levels be checked in men prior and during methadone and other opioid therapy, in order to detect and treat testosterone deficiency associated with opioids and lead to successful methadone treatment outcomes.
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spelling pubmed-41437682014-08-27 Methadone induces testosterone suppression in patients with opioid addiction Bawor, Monica Dennis, Brittany B. Samaan, M. Constantine Plater, Carolyn Worster, Andrew Varenbut, Michael Daiter, Jeff Marsh, David C. Desai, Dipika Steiner, Meir Anglin, Rebecca Coote, Margaret Pare, Guillaume Thabane, Lehana Samaan, Zainab Sci Rep Article Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to methadone treatment for opioid dependence is unclear. The present multi-centre cross-sectional study consecutively recruited 231 patients with opioid dependence from methadone clinics across Ontario, Canada between June and December of 2011. We obtained demographic details, substance use, psychiatric history, and blood and urine samples from enrolled subjects. The control group included 783 non-opioid using adults recruited from a primary care setting in Ontario, Canada. Average testosterone level in men receiving methadone treatment was significantly lower than controls. No effect of opioids including methadone on testosterone level in women was found and testosterone did not fluctuate significantly between menstrual cycle phases. In methadone patients, testosterone level was significantly associated with methadone dose in men only. We recommend that testosterone levels be checked in men prior and during methadone and other opioid therapy, in order to detect and treat testosterone deficiency associated with opioids and lead to successful methadone treatment outcomes. Nature Publishing Group 2014-08-26 /pmc/articles/PMC4143768/ /pubmed/25155550 http://dx.doi.org/10.1038/srep06189 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Article
Bawor, Monica
Dennis, Brittany B.
Samaan, M. Constantine
Plater, Carolyn
Worster, Andrew
Varenbut, Michael
Daiter, Jeff
Marsh, David C.
Desai, Dipika
Steiner, Meir
Anglin, Rebecca
Coote, Margaret
Pare, Guillaume
Thabane, Lehana
Samaan, Zainab
Methadone induces testosterone suppression in patients with opioid addiction
title Methadone induces testosterone suppression in patients with opioid addiction
title_full Methadone induces testosterone suppression in patients with opioid addiction
title_fullStr Methadone induces testosterone suppression in patients with opioid addiction
title_full_unstemmed Methadone induces testosterone suppression in patients with opioid addiction
title_short Methadone induces testosterone suppression in patients with opioid addiction
title_sort methadone induces testosterone suppression in patients with opioid addiction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143768/
https://www.ncbi.nlm.nih.gov/pubmed/25155550
http://dx.doi.org/10.1038/srep06189
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