A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs

Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystalliz...

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Detalles Bibliográficos
Autores principales: Liu, Tian, Guo, Peng, Zhou, Yong, Wang, Jing, Chen, Lei, Yang, Huibin, Qian, Xuhong, Yang, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143770/
https://www.ncbi.nlm.nih.gov/pubmed/25155420
http://dx.doi.org/10.1038/srep06188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143770/
https://www.ncbi.nlm.nih.gov/pubmed/25155420
http://dx.doi.org/10.1038/srep06188

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