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A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two β-GlcNAcase homologs

Selective inhibition of function-specific β-GlcNAcase has great potential in terms of drug design and biological research. The symmetrical bis-naphthalimide M-31850 was previously obtained by screening for specificity against human glycoconjugate-lytic β-GlcNAcase. Using protein-ligand co-crystalliz...

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Detalles Bibliográficos
Autores principales:	Liu, Tian, Guo, Peng, Zhou, Yong, Wang, Jing, Chen, Lei, Yang, Huibin, Qian, Xuhong, Yang, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143770/ https://www.ncbi.nlm.nih.gov/pubmed/25155420 http://dx.doi.org/10.1038/srep06188

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