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Sources of superoxide/H(2)O(2) during mitochondrial proline oxidation

p53 Inducible gene 6 (PIG6) encodes mitochondrial proline dehydrogenase (PRODH) and is up-regulated several fold upon p53 activation. Proline dehydrogenase is proposed to generate radicals that contribute to cancer cell apoptosis. However, there are at least 10 mitochondrial sites that can produce s...

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Detalles Bibliográficos
Autores principales:	Goncalves, Renata L.S., Rothschild, Daniel E., Quinlan, Casey L., Scott, Gary K., Benz, Christopher C., Brand, Martin D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143814/ https://www.ncbi.nlm.nih.gov/pubmed/25184115 http://dx.doi.org/10.1016/j.redox.2014.07.003

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