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Human Leptospirosis Trends: Northeast Thailand, 2001–2012

The objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Th...

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Autores principales: Thipmontree, Wilawan, Suputtamongkol, Yupin, Tantibhedhyangkul, Wiwit, Suttinont, Chuanpit, Wongswat, Ekkarat, Silpasakorn, Saowaluk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143876/
https://www.ncbi.nlm.nih.gov/pubmed/25141000
http://dx.doi.org/10.3390/ijerph110808542
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author Thipmontree, Wilawan
Suputtamongkol, Yupin
Tantibhedhyangkul, Wiwit
Suttinont, Chuanpit
Wongswat, Ekkarat
Silpasakorn, Saowaluk
author_facet Thipmontree, Wilawan
Suputtamongkol, Yupin
Tantibhedhyangkul, Wiwit
Suttinont, Chuanpit
Wongswat, Ekkarat
Silpasakorn, Saowaluk
author_sort Thipmontree, Wilawan
collection PubMed
description The objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Thailand between July 2001 to December 2002 and between July 2011 to December 2012. During the first period, leptospirosis (98 patients, 40%) and scrub typhus (59 patients, 24.1%) were the two major causes of AUFI. In the second period, scrub typhus (137 patients, 28.3%) was found to be more common than leptospirosis (61 patients, 12.7%). Amongst patients with leptospirosis, the proportion of male patients and the median age were similar. Leptospira interrogans serogroup Autumnalis was the major infecting serogroup in both study periods. The case fatality rate of leptospirosis was significantly higher in 2011–2012 as compared with the case fatality rate in 2001–2002 (19.7% vs. 6.3%, p < 0.001). In summary, we found that number of leptospirosis cases had decreased over time. This trend is similar to reportable data for leptospirosis complied from passive surveillance by the Ministry of Public Health, Thailand. However, the case fatality rate of severe leptospirosis has increased. Severe lung hemorrhage associated with leptospirosis remained the major cause of death.
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spelling pubmed-41438762014-08-26 Human Leptospirosis Trends: Northeast Thailand, 2001–2012 Thipmontree, Wilawan Suputtamongkol, Yupin Tantibhedhyangkul, Wiwit Suttinont, Chuanpit Wongswat, Ekkarat Silpasakorn, Saowaluk Int J Environ Res Public Health Article The objective of this study was to determine the changing trend of leptospirosis over time in Thailand using two prospective hospital-based studies conducted amongst adult patients with acute undifferentiated fever (AUFI) admitted to Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima Province, Thailand between July 2001 to December 2002 and between July 2011 to December 2012. During the first period, leptospirosis (98 patients, 40%) and scrub typhus (59 patients, 24.1%) were the two major causes of AUFI. In the second period, scrub typhus (137 patients, 28.3%) was found to be more common than leptospirosis (61 patients, 12.7%). Amongst patients with leptospirosis, the proportion of male patients and the median age were similar. Leptospira interrogans serogroup Autumnalis was the major infecting serogroup in both study periods. The case fatality rate of leptospirosis was significantly higher in 2011–2012 as compared with the case fatality rate in 2001–2002 (19.7% vs. 6.3%, p < 0.001). In summary, we found that number of leptospirosis cases had decreased over time. This trend is similar to reportable data for leptospirosis complied from passive surveillance by the Ministry of Public Health, Thailand. However, the case fatality rate of severe leptospirosis has increased. Severe lung hemorrhage associated with leptospirosis remained the major cause of death. MDPI 2014-08-20 2014-08 /pmc/articles/PMC4143876/ /pubmed/25141000 http://dx.doi.org/10.3390/ijerph110808542 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Thipmontree, Wilawan
Suputtamongkol, Yupin
Tantibhedhyangkul, Wiwit
Suttinont, Chuanpit
Wongswat, Ekkarat
Silpasakorn, Saowaluk
Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_full Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_fullStr Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_full_unstemmed Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_short Human Leptospirosis Trends: Northeast Thailand, 2001–2012
title_sort human leptospirosis trends: northeast thailand, 2001–2012
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143876/
https://www.ncbi.nlm.nih.gov/pubmed/25141000
http://dx.doi.org/10.3390/ijerph110808542
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