Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Diabetes is characterized by hyperglycaemia due to impaired insulin secretion and aberrant glucagon secretion resulting from changes in pancreatic islet cell function and/or mass. The extent to which hyperglycaemia per se underlies these alterations remains poorly understood. Here we show that β-cel...

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Detalles Bibliográficos
Autores principales: Brereton, Melissa F., Iberl, Michaela, Shimomura, Kenju, Zhang, Quan, Adriaenssens, Alice E., Proks, Peter, Spiliotis, Ioannis I., Dace, William, Mattis, Katia K., Ramracheya, Reshma, Gribble, Fiona M., Reimann, Frank, Clark, Anne, Rorsman, Patrik, Ashcroft, Frances M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143961/
https://www.ncbi.nlm.nih.gov/pubmed/25145789
http://dx.doi.org/10.1038/ncomms5639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143961/
https://www.ncbi.nlm.nih.gov/pubmed/25145789
http://dx.doi.org/10.1038/ncomms5639

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