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Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
BACKGROUND: Psoriasis is a chronic, autoimmune, inflammatory papulosquamous disorder, the treatment of which remains challenging. A variety of therapeutic modalities have been used with varying degree of success. But, there is no such therapeutic modality till date that can prevent the relapse in ps...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144213/ https://www.ncbi.nlm.nih.gov/pubmed/25165645 http://dx.doi.org/10.4103/2229-5178.137779 |
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author | Mahajan, Bharat Bhushan Singla, Monika |
author_facet | Mahajan, Bharat Bhushan Singla, Monika |
author_sort | Mahajan, Bharat Bhushan |
collection | PubMed |
description | BACKGROUND: Psoriasis is a chronic, autoimmune, inflammatory papulosquamous disorder, the treatment of which remains challenging. A variety of therapeutic modalities have been used with varying degree of success. But, there is no such therapeutic modality till date that can prevent the relapse in psoriasis. AIMS: The present study is being undertaken to evaluate the therapeutic efficacy of intralesional 5% 5-fluorouracil (5-FU) as well as its role in preventing relapse in resistant localized plaque psoriasis. STUDY DESIGN: An open, prospective, randomized-controlled study. MATERIALS AND METHODS: A total of 40 patients of resistant localized plaque psoriasis were enrolled for the study. Intralesional injection of 5% 5-FU was given in a dosage of 0.1 mL/cm(2) of each plaque using an insulin syringe. In all patients, a single plaque was kept as control and was given intralesional injection of distilled water. A total of three injections were given in each plaque at weekly intervals. After that, patients were followed-up regularly at the interval of 2 weeks up to 12 weeks. All the lesions (both treated and control) were assessed clinically as well as photographically at each visit and graded using psoriasis severity index scoring. Results were analyzed statistically at the end of the follow-up period. RESULTS: At 12 weeks follow-up, out of 40 patients treated, 4 (10%) patients had clearance (>90% resolution), 19 (47.5%) had excellent (70%-90%) improvement, whereas 12 (30%) patients were moderately (30%-70%) improved, and only 5 (12.5%) patients had mild or no improvement. Results were statistically significant in treated group in comparison to control group. Almost all patients complained of pain at the site of injection which subsided within 1-2 h. A total of 10 (25%) patients had necrosis after one or two injections which healed during the follow-up period within 6-8 weeks. CONCLUSION: Intralesional 5% 5-FU is found to be an effective therapeutic modality in resistant localized plaque psoriasis without much side effects. |
format | Online Article Text |
id | pubmed-4144213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41442132014-08-27 Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis Mahajan, Bharat Bhushan Singla, Monika Indian Dermatol Online J Original Article BACKGROUND: Psoriasis is a chronic, autoimmune, inflammatory papulosquamous disorder, the treatment of which remains challenging. A variety of therapeutic modalities have been used with varying degree of success. But, there is no such therapeutic modality till date that can prevent the relapse in psoriasis. AIMS: The present study is being undertaken to evaluate the therapeutic efficacy of intralesional 5% 5-fluorouracil (5-FU) as well as its role in preventing relapse in resistant localized plaque psoriasis. STUDY DESIGN: An open, prospective, randomized-controlled study. MATERIALS AND METHODS: A total of 40 patients of resistant localized plaque psoriasis were enrolled for the study. Intralesional injection of 5% 5-FU was given in a dosage of 0.1 mL/cm(2) of each plaque using an insulin syringe. In all patients, a single plaque was kept as control and was given intralesional injection of distilled water. A total of three injections were given in each plaque at weekly intervals. After that, patients were followed-up regularly at the interval of 2 weeks up to 12 weeks. All the lesions (both treated and control) were assessed clinically as well as photographically at each visit and graded using psoriasis severity index scoring. Results were analyzed statistically at the end of the follow-up period. RESULTS: At 12 weeks follow-up, out of 40 patients treated, 4 (10%) patients had clearance (>90% resolution), 19 (47.5%) had excellent (70%-90%) improvement, whereas 12 (30%) patients were moderately (30%-70%) improved, and only 5 (12.5%) patients had mild or no improvement. Results were statistically significant in treated group in comparison to control group. Almost all patients complained of pain at the site of injection which subsided within 1-2 h. A total of 10 (25%) patients had necrosis after one or two injections which healed during the follow-up period within 6-8 weeks. CONCLUSION: Intralesional 5% 5-FU is found to be an effective therapeutic modality in resistant localized plaque psoriasis without much side effects. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4144213/ /pubmed/25165645 http://dx.doi.org/10.4103/2229-5178.137779 Text en Copyright: © Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mahajan, Bharat Bhushan Singla, Monika Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis |
title | Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
|
title_full | Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
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title_fullStr | Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
|
title_full_unstemmed | Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
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title_short | Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis
|
title_sort | evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144213/ https://www.ncbi.nlm.nih.gov/pubmed/25165645 http://dx.doi.org/10.4103/2229-5178.137779 |
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