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Acute effects of smoking on QT dispersion in healthy males
BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144371/ https://www.ncbi.nlm.nih.gov/pubmed/25161676 |
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author | Akbarzadeh, Mohammad Ali Yazdani, Shahrooz Ghaidari, Mohamad Esmail Asadpour-Piranfar, Mohammad Bahrololoumi-Bafruee, Negar Golabchi, Allahyar Azhari, Amirhossein |
author_facet | Akbarzadeh, Mohammad Ali Yazdani, Shahrooz Ghaidari, Mohamad Esmail Asadpour-Piranfar, Mohammad Bahrololoumi-Bafruee, Negar Golabchi, Allahyar Azhari, Amirhossein |
author_sort | Akbarzadeh, Mohammad Ali |
collection | PubMed |
description | BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on QT interval and QTD in healthy smokers and nonsmokers. METHODS: The study sample population consisted of 40 healthy male hospital staff, including 20 smokers and 20 nonsmokers. They were asked to refrain from smoking at least 6 h before attending the study. A 12-lead surface electrocardiogram (ECG), recorded at paper speed of 50 mm/s, was obtained from all participants before and 10 min after smoking of a single complete cigarette. QT interval, corrected QT interval, QTD, and corrected QT dispersion (QTcD) were measured before and after smoking. RESULTS: Smokers and nonsmokers did not have any significant differences in heart rate (HR) (before smoking = 67.35 ± 5.14 vs. 67.70 ± 5.07, after smoking = 76.70 ± 6.50 vs. 76.85 ± 6.50, respectively), QTD (before smoking = 37.75 ± 7.16 vs. 39.15 ± 6.55, after smoking = 44.75 ± 11.97 vs. 45.50 ± 9.58, respectively), and QTcD (before smoking = 39.85 ± 7.40 vs. 41.55 ± 6.57, after smoking = 50.70 ± 14.31 vs. 51.50 ± 11.71, respectively). However, after smoking a single cigarette, HR, mean QTD, and QTcD significantly increased (all had P value <0.001) in comparison to the measures before smoking. CONCLUSION: Smoking of a single complete cigarette in both smokers and nonsmokers results in significant QTD increase, which can cause arrhythmia and SCD. |
format | Online Article Text |
id | pubmed-4144371 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-41443712014-08-26 Acute effects of smoking on QT dispersion in healthy males Akbarzadeh, Mohammad Ali Yazdani, Shahrooz Ghaidari, Mohamad Esmail Asadpour-Piranfar, Mohammad Bahrololoumi-Bafruee, Negar Golabchi, Allahyar Azhari, Amirhossein ARYA Atheroscler Original Article BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on QT interval and QTD in healthy smokers and nonsmokers. METHODS: The study sample population consisted of 40 healthy male hospital staff, including 20 smokers and 20 nonsmokers. They were asked to refrain from smoking at least 6 h before attending the study. A 12-lead surface electrocardiogram (ECG), recorded at paper speed of 50 mm/s, was obtained from all participants before and 10 min after smoking of a single complete cigarette. QT interval, corrected QT interval, QTD, and corrected QT dispersion (QTcD) were measured before and after smoking. RESULTS: Smokers and nonsmokers did not have any significant differences in heart rate (HR) (before smoking = 67.35 ± 5.14 vs. 67.70 ± 5.07, after smoking = 76.70 ± 6.50 vs. 76.85 ± 6.50, respectively), QTD (before smoking = 37.75 ± 7.16 vs. 39.15 ± 6.55, after smoking = 44.75 ± 11.97 vs. 45.50 ± 9.58, respectively), and QTcD (before smoking = 39.85 ± 7.40 vs. 41.55 ± 6.57, after smoking = 50.70 ± 14.31 vs. 51.50 ± 11.71, respectively). However, after smoking a single cigarette, HR, mean QTD, and QTcD significantly increased (all had P value <0.001) in comparison to the measures before smoking. CONCLUSION: Smoking of a single complete cigarette in both smokers and nonsmokers results in significant QTD increase, which can cause arrhythmia and SCD. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2014-03 /pmc/articles/PMC4144371/ /pubmed/25161676 Text en © 2014 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Original Article Akbarzadeh, Mohammad Ali Yazdani, Shahrooz Ghaidari, Mohamad Esmail Asadpour-Piranfar, Mohammad Bahrololoumi-Bafruee, Negar Golabchi, Allahyar Azhari, Amirhossein Acute effects of smoking on QT dispersion in healthy males |
title | Acute effects of smoking on QT dispersion in healthy males |
title_full | Acute effects of smoking on QT dispersion in healthy males |
title_fullStr | Acute effects of smoking on QT dispersion in healthy males |
title_full_unstemmed | Acute effects of smoking on QT dispersion in healthy males |
title_short | Acute effects of smoking on QT dispersion in healthy males |
title_sort | acute effects of smoking on qt dispersion in healthy males |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144371/ https://www.ncbi.nlm.nih.gov/pubmed/25161676 |
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