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Acute effects of smoking on QT dispersion in healthy males

BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on...

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Autores principales: Akbarzadeh, Mohammad Ali, Yazdani, Shahrooz, Ghaidari, Mohamad Esmail, Asadpour-Piranfar, Mohammad, Bahrololoumi-Bafruee, Negar, Golabchi, Allahyar, Azhari, Amirhossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2014
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144371/
https://www.ncbi.nlm.nih.gov/pubmed/25161676
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author Akbarzadeh, Mohammad Ali
Yazdani, Shahrooz
Ghaidari, Mohamad Esmail
Asadpour-Piranfar, Mohammad
Bahrololoumi-Bafruee, Negar
Golabchi, Allahyar
Azhari, Amirhossein
author_facet Akbarzadeh, Mohammad Ali
Yazdani, Shahrooz
Ghaidari, Mohamad Esmail
Asadpour-Piranfar, Mohammad
Bahrololoumi-Bafruee, Negar
Golabchi, Allahyar
Azhari, Amirhossein
author_sort Akbarzadeh, Mohammad Ali
collection PubMed
description BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on QT interval and QTD in healthy smokers and nonsmokers. METHODS: The study sample population consisted of 40 healthy male hospital staff, including 20 smokers and 20 nonsmokers. They were asked to refrain from smoking at least 6 h before attending the study. A 12-lead surface electrocardiogram (ECG), recorded at paper speed of 50 mm/s, was obtained from all participants before and 10 min after smoking of a single complete cigarette. QT interval, corrected QT interval, QTD, and corrected QT dispersion (QTcD) were measured before and after smoking. RESULTS: Smokers and nonsmokers did not have any significant differences in heart rate (HR) (before smoking = 67.35 ± 5.14 vs. 67.70 ± 5.07, after smoking = 76.70 ± 6.50 vs. 76.85 ± 6.50, respectively), QTD (before smoking = 37.75 ± 7.16 vs. 39.15 ± 6.55, after smoking = 44.75 ± 11.97 vs. 45.50 ± 9.58, respectively), and QTcD (before smoking = 39.85 ± 7.40 vs. 41.55 ± 6.57, after smoking = 50.70 ± 14.31 vs. 51.50 ± 11.71, respectively). However, after smoking a single cigarette, HR, mean QTD, and QTcD significantly increased (all had P value <0.001) in comparison to the measures before smoking. CONCLUSION: Smoking of a single complete cigarette in both smokers and nonsmokers results in significant QTD increase, which can cause arrhythmia and SCD.
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spelling pubmed-41443712014-08-26 Acute effects of smoking on QT dispersion in healthy males Akbarzadeh, Mohammad Ali Yazdani, Shahrooz Ghaidari, Mohamad Esmail Asadpour-Piranfar, Mohammad Bahrololoumi-Bafruee, Negar Golabchi, Allahyar Azhari, Amirhossein ARYA Atheroscler Original Article BACKGROUND: Cigarette smoking increases the risk of ventricular fibrillation and sudden cardiac death (SCD). QT dispersion (QTD) is an important predictor of cardiac arrhythmia. The aim of this study was to assess the acute effect of smoking a single standard cigarette containing 1.7 mg nicotine on QT interval and QTD in healthy smokers and nonsmokers. METHODS: The study sample population consisted of 40 healthy male hospital staff, including 20 smokers and 20 nonsmokers. They were asked to refrain from smoking at least 6 h before attending the study. A 12-lead surface electrocardiogram (ECG), recorded at paper speed of 50 mm/s, was obtained from all participants before and 10 min after smoking of a single complete cigarette. QT interval, corrected QT interval, QTD, and corrected QT dispersion (QTcD) were measured before and after smoking. RESULTS: Smokers and nonsmokers did not have any significant differences in heart rate (HR) (before smoking = 67.35 ± 5.14 vs. 67.70 ± 5.07, after smoking = 76.70 ± 6.50 vs. 76.85 ± 6.50, respectively), QTD (before smoking = 37.75 ± 7.16 vs. 39.15 ± 6.55, after smoking = 44.75 ± 11.97 vs. 45.50 ± 9.58, respectively), and QTcD (before smoking = 39.85 ± 7.40 vs. 41.55 ± 6.57, after smoking = 50.70 ± 14.31 vs. 51.50 ± 11.71, respectively). However, after smoking a single cigarette, HR, mean QTD, and QTcD significantly increased (all had P value <0.001) in comparison to the measures before smoking. CONCLUSION: Smoking of a single complete cigarette in both smokers and nonsmokers results in significant QTD increase, which can cause arrhythmia and SCD. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences 2014-03 /pmc/articles/PMC4144371/ /pubmed/25161676 Text en © 2014 Isfahan Cardiovascular Research Center & Isfahan University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Akbarzadeh, Mohammad Ali
Yazdani, Shahrooz
Ghaidari, Mohamad Esmail
Asadpour-Piranfar, Mohammad
Bahrololoumi-Bafruee, Negar
Golabchi, Allahyar
Azhari, Amirhossein
Acute effects of smoking on QT dispersion in healthy males
title Acute effects of smoking on QT dispersion in healthy males
title_full Acute effects of smoking on QT dispersion in healthy males
title_fullStr Acute effects of smoking on QT dispersion in healthy males
title_full_unstemmed Acute effects of smoking on QT dispersion in healthy males
title_short Acute effects of smoking on QT dispersion in healthy males
title_sort acute effects of smoking on qt dispersion in healthy males
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144371/
https://www.ncbi.nlm.nih.gov/pubmed/25161676
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