Differences in the regulation of RyR2 from human, sheep, and rat by Ca(2+) and Mg(2+) in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca(2+) and Mg(2+) plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca(2+)- and Mg(2+)-dependent regulation of human RyR2 was recorded in ar...

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Detalles Bibliográficos
Autores principales: Walweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S., Quail, Anthony, dos Remedios, Cris G., Beard, Nicole A., Dulhunty, Angela F., van Helden, Dirk F., Laver, Derek R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144672/
https://www.ncbi.nlm.nih.gov/pubmed/25156119
http://dx.doi.org/10.1085/jgp.201311157

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