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Dual Specificity and Novel Structural Folding of Yeast Phosphodiesterase-1 for Hydrolysis of Second Messengers Cyclic Adenosine and Guanosine 3′,5′-Monophosphate

[Image: see text] Cyclic nucleotide phosphodiesterases (PDEs) decompose second messengers cAMP and cGMP that play critical roles in many physiological processes. PDE1 of Saccharomyces cerevisiae has been subcloned and expressed in Escherichia coli. Recombinant yPDE1 has a K(M) of 110 μM and a k(cat)...

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Detalles Bibliográficos
Autores principales:	Tian, Yuanyuan, Cui, Wenjun, Huang, Manna, Robinson, Howard, Wan, Yiqian, Wang, Yousheng, Ke, Hengming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144708/ https://www.ncbi.nlm.nih.gov/pubmed/25050706 http://dx.doi.org/10.1021/bi500406h

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