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Characterization of the Lipid Binding Properties of Otoferlin Reveals Specific Interactions between PI(4,5)P2 and the C2C and C2F Domains

[Image: see text] Otoferlin is a transmembrane protein consisting of six C2 domains, proposed to act as a calcium sensor for exocytosis. Although otoferlin is believed to bind calcium and lipids, the lipid specificity and identity of the calcium binding domains are controversial. Further, it is curr...

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Detalles Bibliográficos
Autores principales:	Padmanarayana, Murugesh, Hams, Nicole, Speight, Lee C., Petersson, E. James, Mehl, Ryan A., Johnson, Colin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144714/ https://www.ncbi.nlm.nih.gov/pubmed/24999532 http://dx.doi.org/10.1021/bi5004469

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