Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

Stat3 signaling is essential for the induction of RORγt and subsequent Th17 cell differentiation. However, the downstream targets of Stat3 for RORγt expression remain largely unknown. We show here that a novel isoform of Sox5, named Sox5t, is induced in Th17 cells in a Stat3-dependent manner. In viv...

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Detalles Bibliográficos
Autores principales: Tanaka, Shigeru, Suto, Akira, Iwamoto, Taro, Kashiwakuma, Daisuke, Kagami, Shin-ichiro, Suzuki, Kotaro, Takatori, Hiroaki, Tamachi, Tomohiro, Hirose, Koichi, Onodera, Atsushi, Suzuki, Junpei, Ohara, Osamu, Yamashita, Masakatsu, Nakayama, Toshinori, Nakajima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144730/
https://www.ncbi.nlm.nih.gov/pubmed/25073789
http://dx.doi.org/10.1084/jem.20130791

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