RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement

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V(D)J recombination of TCR loci is regulated by chromatin accessibility to RAG1/2 proteins, rendering RAG1/2 targeting a potentially important regulator of lymphoid differentiation. We show that within the human TCR-α/δ locus, Dδ2-Dδ3 rearrangements occur at a very immature thymic, CD34(+)/CD1a(−)/C...

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Detalles Bibliográficos
Autores principales: Cieslak, Agata, Le Noir, Sandrine, Trinquand, Amélie, Lhermitte, Ludovic, Franchini, Don-Marc, Villarese, Patrick, Gon, Stéphanie, Bond, Jonathan, Simonin, Mathieu, Vanhille, Laurent, Reimann, Christian, Verhoeyen, Els, Larghero, Jerome, Six, Emmanuelle, Spicuglia, Salvatore, André-Schmutz, Isabelle, Langerak, Anton, Nadel, Bertrand, Macintyre, Elizabeth, Payet-Bornet, Dominique, Asnafi, Vahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144731/
https://www.ncbi.nlm.nih.gov/pubmed/25135298
http://dx.doi.org/10.1084/jem.20132585

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